APE1L Antibody

Datasheet

Code	CSB-PA443368XA01DOA
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Product Details
Customer Reviews and Q&A
Target Background

Product Details

Full Product Name

Rabbit anti-Arabidopsis thaliana (Mouse-ear cress) APE1L Polyclonal antibody

Uniprot No.

Q5XF07

Target Names

APE1L

Alternative Names

APE1L antibody; At3g48425 antibody; T29H11.60DNA-(apurinic or apyrimidinic site) lyase antibody; EC 3.1.-.- antibody; EC 4.2.99.18 antibody; APEX1-like protein antibody; Apurinic-apyrimidinic endonuclease antibody

Raised in

Rabbit

Species Reactivity

Arabidopsis thaliana

Immunogen

Recombinant Arabidopsis thaliana APE1L protein

Immunogen Species

Arabidopsis thaliana (Mouse-ear cress)

Conjugate

Non-conjugated

Clonality

Polyclonal

Isotype

IgG

Purification Method

Antigen Affinity Purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form

Liquid

Tested Applications

ELISA, WB (ensure identification of antigen)

Protocols

ELISA Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Value-added Deliverables

① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);

Quality Guarantee

① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;

Lead Time

Made-to-order (14-16 weeks)

Customer Reviews and Q&A

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Target Background

Function

Apurinic/apyrimidinic (AP) endonuclease involved in active DNA demethylation and gene imprinting. According to a report, displays also an in vitro 3'-phosphatase activity. According to another report, has no in vitro 3'-phosphatase activity. Catalyzes the conversion of the 3'-blocking groups 3'-phosphor-alpha,beta-unsaturated aldehyde (3'-PUA) generated by ROS1 to 3'-OH. Has a strong non-specific affinity to DNA. Redundant with APE2 and at least one functional allele is required for seed viability.

Gene References into Functions

APE1L is a new component of the active DNA demethylation pathway and, together with ZDP, regulates gene imprinting in Arabidopsis. [APE1L] PMID: 25569774
self-crosses of heterozygous mutants of Ape1L, Ape2, and Arp show that full development of an embryo requires at least one wild-type copy of either Ape1L or Ape2. [Ape1L] PMID: 19172180

Subcellular Location

Nucleus. Nucleus, nucleolus.

Protein Families

DNA repair enzymes AP/exoA family

Tissue Specificity

Expressed in leaves, flower buds and developing siliques. Not detected in roots.

Database Links

KEGG: ath:AT3G48425

STRING: 3702.AT3G48425.1

UniGene: At.50257

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Service

Phage Display Service

Antibody Service

Protein Service

Gene Synthesis Service

Oligo Synthesis Service

Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

Call us

301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

[email protected]

Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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