aPKC Antibody

1. We first demonstrate that Hook2 is essential for the polarized Golgi re-orientation towards the migration front. Depletion of Hook2 results in a decrease of PAR6alpha at the centrosome during cell migration, while overexpression of Hook2 in cells induced the formation of aggresomes with the recruitment of PAR6alpha, aPKC and PAR3 PMID: 27624926
2. aPKC, spatially controlled by the Crb complex, is a key polarity molecule coordinating the generation of three distinct but interconnected cell polarities during collective migration. PMID: 29636381
3. Candidate proteins with strong PRBH signals associated with the cell cortex but were displaced into the cytoplasm by aPKC. These findings demonstrate a potentially general mechanism for exclusion of proteins from the Par cortical domain in polarized cells PMID: 26481050
4. Slmb restricts the activity of aPKC to polarize epithelial cells PMID: 25053431
5. precise regulation of cortical aPKC kinase activity distinguishes the sibling cell identity in part by ensuring asymmetric partitioning of Numb into the future progenitor cell where Numb maintains restricted potential independently of regulation by aPKC PMID: 22394487
6. Crumbs anisotropy leads to anisotropic distribution of aPKC, which in turn can negatively regulate Rok, thus preventing the formation of a cable where Crumbs and aPKC are localized. PMID: 23153493
7. It was shown that Drosophila atypical protein kinase C is required in vivo for spindle planar orientation and apical exclusion of Drosophila Pins. PMID: 22223679
8. Data show that Zif is a transcription factor that directly represses aPKC transcription [Zif]. PMID: 21074726
9. The kinase activity of aPKC and its ability to bind PAR-6 are only required for a subset of its functions during development, revealing tissue-specific differences in the way that aPKC controls cell polarity. PMID: 19789180
10. Activities of aPKC (P<0.05) and ERK 1/2 (P=0.06), but not phosphorylation of P38 MAPK, were higher in trained than in sedentary subjects at rest. PMID: 14651992
11. Results show that Drosophila atypical protein kinase C zygotic null mutants survive to mid-larval stages, where they exhibit defects in neuroblast and epithelial cell polarity. PMID: 14657233
12. DaPKC has a role in regulating epithelial cell polarity in Drosophila along with crumbs protein PMID: 15302858
13. cortical aPKC kinase activity is a potent inducer of neuroblast self-renewal PMID: 16357871
14. Phosphorylation of Numb by aPKC regulates its polarized distribution in epithelial cells as well as during asymmetric cell divisions. PMID: 17203073
15. atypical Protein Kinase C (aPKC) is required for symmetric adherens junction positioning during Drosophila embryogenesis. PMID: 17488624
16. found that other aPKC mutant alleles exhibit suppression of the synaptic phenotype caused by over-expression of dominant-negative form of the Glued protein. PMID: 19948010

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KEGG: dme:Dmel_CG42783

STRING: 7227.FBpp0302921

UniGene: Dm.1507