Crz Antibody

Code CSB-PA630616XA01DLU
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Product Details

Full Product Name
Rabbit anti-Drosophila melanogaster (Fruit fly) Crz Polyclonal antibody
Uniprot No.
Target Names
Crz
Alternative Names
Crz antibody; CG3302Pro-corazonin antibody; Crz antibody; Dm-Crz) [Cleaved into: Corazonin; Corazonin precursor-related peptide antibody; CPRP antibody; Crz-associated peptide)] antibody
Raised in
Rabbit
Species Reactivity
Drosophila melanogaster (Fruit fly)
Immunogen
Recombinant Drosophila melanogaster (Fruit fly) Crz protein
Immunogen Species
Drosophila melanogaster (Fruit fly)
Conjugate
Non-conjugated
Clonality
Polyclonal
Isotype
IgG
Purification Method
Antigen Affinity Purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Tested Applications
ELISA, WB (ensure identification of antigen)
Protocols
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Value-added Deliverables
① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);
Quality Guarantee
① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;
Lead Time
Made-to-order (14-16 weeks)

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Target Background

Function
Cardioactive peptide. Corazonin is probably involved in the physiological regulation of the heart beat. Clock (Clk) and cycle (cyc) proteins negatively regulate Crz transcription in a cell-specific manner.
Gene References into Functions
  1. Loss of Atg16 delays the alcohol-induced sedation response via regulation of Corazonin neuropeptide production in Drosophila. PMID: 27708416
  2. Results show that the Crz action triggers transcriptional changes in the adipocytes that include stress genes and one gene involved in metabolism. PMID: 27810969
  3. Data show that altered corazonin neuron physiology leads to fundamental differences in locomotor activity, and these effects were also sex-dependent. PMID: 20161767
  4. provide evidence showing that a group of neurons (vCrz) that express neuropeptide Corazonin (Crz) gene in the ventral nerve cord of the larval central nervous system undergo programmed death within 6 hours of the onset of metamorphosis PMID: 16672345
  5. The tissue-, stage-, and sex-specific expression of Crz and the association of Crz with the function of the retrocerebral complex suggest diverse roles for this neuropeptide in Drosophila. PMID: 18087727
  6. We show that the 504-bp 5' upstream sequence is the shortest promoter directing reporter activities in all Drosophila Corazonin neurons. PMID: 18181151

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Subcellular Location
[Corazonin]: Secreted.; [Corazonin precursor-related peptide]: Secreted.
Protein Families
Corazonin family
Tissue Specificity
From late embryo to larva, expression is consistently detected in three neuronal groups: dorso-lateral neurons (DL), dorso-medial neurons (DM), and neurons in the ventral nerve cord (vCrz). Both the vCrz and DM groups die via programmed cell death during
Database Links

KEGG: dme:Dmel_CG3302

STRING: 7227.FBpp0082386

UniGene: Dm.2429

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