Capa Antibody

Code CSB-PA873597XA01DLU
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Product Details

Full Product Name
Rabbit anti-Drosophila melanogaster (Fruit fly) Capa Polyclonal antibody
Uniprot No.
Target Names
Capa
Alternative Names
Capa antibody; MT-CAP2b antibody; CG15520Cardio acceleratory peptide 2b antibody; Capability protein antibody; Myotropin-CAP2b-like protein) [Cleaved into: CAP-1 antibody; CAP2b-1 antibody; Capa-1); CAP-2 antibody; CAP2b-2 antibody; Capa-2); CAP-3 antibody; CAP2b-3 antibody; Capa-3 antibody; Myotropin antibody; Pyrokinin-1)] antibody
Raised in
Rabbit
Species Reactivity
Drosophila melanogaster (Fruit fly)
Immunogen
Recombinant Drosophila melanogaster (Fruit fly) Capa protein
Immunogen Species
Drosophila melanogaster (Fruit fly)
Conjugate
Non-conjugated
Clonality
Polyclonal
Isotype
IgG
Purification Method
Antigen Affinity Purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Tested Applications
ELISA, WB (ensure identification of antigen)
Protocols
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Value-added Deliverables
① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);
Quality Guarantee
① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;
Lead Time
Made-to-order (14-16 weeks)

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Target Background

Function
CAP-1 and CAP-2, but not CAP-3 are ligands for the Capa receptor. CAP-1 and CAP-2 are probably components of the signal transduction pathway that leads to Malpighian tubule fluid secretion via the second messenger nitric oxide. CAP-3 is a ligand for the PK1-R G-protein coupled receptor.
Gene References into Functions
  1. regulation of cellular ion and water homeostasis mediated by capa peptide signaling in the insect Malpighian (renal) tubules is a key physiological mechanism during recovery from desiccation and cold stress. PMID: 25730885
  2. Developmental appearance of the peptidergic, Capability-expressing Va neurons PMID: 21354130
  3. 99D on chromosome 3R potentially encodes GANMGLYAFPRV-amide (capa-1), ASGLVAFPRV-amide (capa-2), and TGPSASSGLWGPRL-amide (capa-3). neuroendocrine cells release capa peptides into hemolymph PMID: 11959669
Subcellular Location
Secreted. Note=Released from the neuroendocrine cells into the hemolymph.
Protein Families
Pyrokinin family
Tissue Specificity
In larvae, the precursor peptide is exclusively present in a single pair of neuroendocrine cells in the labial neuromere (subesophageal ganglion) and three pairs of cells in the ventral ganglion abdominal neuromeres.
Database Links

KEGG: dme:Dmel_CG15520

STRING: 7227.FBpp0084880

UniGene: Dm.2221

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