CkIIalpha Antibody

Code CSB-PA006072XA01DLU
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Product Details

Full Product Name
Rabbit anti-Drosophila melanogaster (Fruit fly) CkIIalpha Polyclonal antibody
Uniprot No.
Target Names
CkIIalpha
Alternative Names
CkIIalpha antibody; Cask-II-a antibody; CG17520Casein kinase II subunit alpha antibody; CK II subunit alpha antibody; EC 2.7.11.1 antibody
Raised in
Rabbit
Species Reactivity
Drosophila melanogaster (Fruit fly)
Immunogen
Recombinant Drosophila melanogaster (Fruit fly) CkIIalpha protein
Immunogen Species
Drosophila melanogaster (Fruit fly)
Conjugate
Non-conjugated
Clonality
Polyclonal
Isotype
IgG
Purification Method
Antigen Affinity Purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Tested Applications
ELISA, WB (ensure identification of antigen)
Protocols
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Value-added Deliverables
① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);
Quality Guarantee
① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;
Lead Time
Made-to-order (14-16 weeks)

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Target Background

Function
Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. The alpha chain contains the catalytic site. May participate in Wnt signaling.
Gene References into Functions
  1. CK2alpha might be important in regulating synaptic plasticity by modulating the transcription of BRP. Hence, we propose that CK2alpha is a novel regulator of the active zone protein, BRP, in Drosophila. PMID: 24080510
  2. overexpression of Tik elicits ectopic bristles in N(+) flies and suppresses the retinal defects of the gain-of-function allele N(spl). PMID: 19536808
  3. Sequencing of full-length cDNA encoding subunits in platelets and megakaryocytic cells PMID: 12102635
  4. CK2 alpha binds and phosphorylates ribosomal protein L22 PMID: 12379220
  5. CK2alpha mutant flies show lengthened circadian period, decreased CK2 activity, and delayed nuclear entry of Per; these effects are probably direct, as CK2alpha specifically phosphorylates Per in vitro PMID: 12447397
  6. casein kinase II has a role in regulating cAMP-response element-binding protein DNA binding by phosphorylation at specific CK sites PMID: 14676200
  7. Dominant-negative CK2alpha induces potent effects on circadian rhythmicity. PMID: 18208335
  8. Results describe the isolation of temperature-sensitive alleles of Drosophila CK2alpha. PMID: 19039653

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Subcellular Location
Nucleus, nucleolus.
Protein Families
Protein kinase superfamily, Ser/Thr protein kinase family, CK2 subfamily
Database Links

KEGG: dme:Dmel_CG17520

STRING: 7227.FBpp0110433

UniGene: Dm.1750

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