TIS11 Antibody

Code CSB-PA343701XA01SVG
Size Enquire
Have Questions? Leave a Message or Start an on-line Chat

Product Details

Full Product Name
Rabbit anti-Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) TIS11 Polyclonal antibody
Uniprot No.
Target Names
TIS11
Alternative Names
TIS11 antibody; CTH2 antibody; YLR136C antibody; L3143 antibody; L9606.12mRNA decay factor CTH2 antibody; Cysteine-three-histidine protein 2 antibody; Protein TIS11 homolog antibody; Protein YTIS11 antibody; TPA-induced sequence protein 11 antibody
Raised in
Rabbit
Species Reactivity
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Immunogen
Recombinant Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) TIS11 protein
Immunogen Species
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Conjugate
Non-conjugated
Clonality
Polyclonal
Isotype
IgG
Purification Method
Antigen Affinity Purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Tested Applications
ELISA, WB (ensure identification of antigen)
Protocols
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Value-added Deliverables
① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);
Quality Guarantee
① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;
Lead Time
Made-to-order (14-16 weeks)

Customer Reviews and Q&A

 Customer Reviews

There are currently no reviews for this product.

Submit a Review here

Target Background

Function
Binds to specific AU-rich elements (ARE) in the 3'-untranslated region of target mRNAs and promotes their degradation. In response to iron deficiency, promotes the decay of many mRNAs encoding proteins involved in iron-dependent pathways. Recruits the DHH1 helicase to the SDH4 mRNA and promotes SDH4 mRNA decay. Also destabilizes target mRNA by modulating 3'-end processing, creating extended transcripts that are prone for degradation.
Gene References into Functions
  1. Results demonstrate that the Cth2 CTD is physiologically relevant for adaptation to iron deficiency. PMID: 29912874
  2. Cth2 protein mediates early adaptation of yeast cells to oxidative stress conditions. PMID: 26824473
  3. Negative feedback regulation of the CTH1 and CTH2 mRNA binding proteins is required for adaptation to iron deficiency and iron supplementation. PMID: 23530061
  4. metabolic reprogramming as a consequence of Fe starvation that is dependent on the coordinated activities of CTH1 and CTH2 PMID: 18522836
  5. Cth2 protein recruits the Dhh1 helicase to ARE-containing mRNAs to promote SDH4 mRNA decay PMID: 18715869

Show More

Hide All

Subcellular Location
Nucleus. Cytoplasm, P-body.
Database Links

KEGG: sce:YLR136C

STRING: 4932.YLR136C

icon of phone
Call us
301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)
icon of address
Address
7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA
icon of social media
Join us with

Subscribe newsletter

Leave a message

* To protect against spam, please pass the CAPTCHA test below.
CAPTCHA verification
© 2007-2024 CUSABIO TECHNOLOGY LLC All rights reserved. 鄂ICP备15011166号-1