Sra-1 Antibody

Datasheet

Code	CSB-PA893270XA01DLU
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Product Details

Full Product Name

Rabbit anti-Drosophila melanogaster (Fruit fly) Sra-1 Polyclonal antibody

Uniprot No.

Q9VF87

Target Names

Sra-1

Alternative Names

Sra-1 antibody; Cyfip antibody; CG4931Cytoplasmic FMR1-interacting protein antibody; Specifically Rac1-associated protein 1 antibody; DSra-1 antibody

Raised in

Rabbit

Species Reactivity

Drosophila melanogaster (Fruit fly)

Immunogen

Recombinant Drosophila melanogaster (Fruit fly) Sra-1 protein

Immunogen Species

Drosophila melanogaster (Fruit fly)

Conjugate

Non-conjugated

Clonality

Polyclonal

Isotype

IgG

Purification Method

Antigen Affinity Purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form

Liquid

Tested Applications

ELISA, WB (ensure identification of antigen)

Protocols

ELISA Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Value-added Deliverables

① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);

Quality Guarantee

① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;

Lead Time

Made-to-order (14-16 weeks)

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Target Background

Function

Plays a role in guidance and morphology of central and peripheral axons and in synaptic morphology. Also required for formation of cell membrane protrusions and for bristle development. Plays a role in regulating mitochondrial activity, energy metabolism and membrane potential which maintains normal gamma-aminobutyric acid (GABA) signaling and ensures normal social behavior.

Gene References into Functions

These results illustrate a new model to explain the cellular roles of FMRP and CYFIP1 and the molecular significance of their interaction. PMID: 28183735
We propose that Cyfip regulates synapse development and endocytosis by inhibiting actin assembly. PMID: 23593037
Mutations in WAVE/SCAR and in ARP2/3 complex subunits but not in WASP, another major regulator of Actin nucleation, phenocopy CYFIP defects. Thus, the CYFIP-SCAR-ARP2/3 pathway orchestrates specific tissue remodeling processes PMID: 21884694
CYFIP specifically expressed in the nervous system; mutations affect axons and synapses, much like mutations in dFMR1 and Rho GTPase dRac1; CYFIP acts as a dRac1 effector that antagonizes FMR1 function PMID: 12818175

Subcellular Location

Cytoplasm.

Protein Families

CYFIP family

Tissue Specificity

In the embryo, expressed mainly in the gut and in the developing central nervous system where high levels of expression are found in the CNS neuropile. Expression in the gut diminishes as development proceeds (at protein level). In the adult, expressed sp

Database Links

KEGG: dme:Dmel_CG4931

STRING: 7227.FBpp0082541

UniGene: Dm.3506

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Service

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Protein Service

Gene Synthesis Service

Oligo Synthesis Service

Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

Call us

301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

[email protected]

Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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Sra-1 Antibody

Product Details

Related Products

Customer Reviews and Q&A

Target Background