degS Antibody

Datasheet

Code	CSB-PA360099XA01EOD
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Target Background

Product Details

Full Product Name

Rabbit anti-Escherichia coli O157:H7 degS Polyclonal antibody

Uniprot No.

P0AEE4

Target Names

degS

Alternative Names

degS antibody; Z4594 antibody; ECs4108Serine endoprotease DegS antibody; EC 3.4.21.107 antibody; Site-1 protease DegS antibody; S1P protease DegS antibody; Site-1-type intramembrane protease antibody

Raised in

Rabbit

Species Reactivity

Escherichia coli O157:H7

Immunogen

Recombinant Escherichia coli O157:H7 degS protein

Immunogen Species

Escherichia coli O157:H7

Conjugate

Non-conjugated

Clonality

Polyclonal

Isotype

IgG

Purification Method

Antigen Affinity Purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form

Liquid

Tested Applications

ELISA, WB (ensure identification of antigen)

Protocols

ELISA Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Value-added Deliverables

① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);

Quality Guarantee

① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;

Lead Time

Made-to-order (14-16 weeks)

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Target Background

Function

A site-1 protease (S1P) that cleaves the peptide bond between 'Val-148' and 'Ser-149' in RseA. Part of a regulated intramembrane proteolysis (RIP) cascade. When heat shock or other environmental stresses disrupt protein folding in the periplasm, DegS senses the accumulation of unassembled outer membrane porins (OMP) and then initiates RseA (anti sigma-E factor) degradation by cleaving its periplasmic domain, making it a substrate for subsequent cleavage by RseP. This cascade ultimately leads to the sigma-E-driven expression of a variety of factors dealing with folding stress in the periplasm and OMP assembly. Required for basal and stress-induced degradation of RseA.

Subcellular Location

Cell inner membrane; Single-pass membrane protein.

Protein Families

Peptidase S1C family

Database Links

KEGG: ece:Z4594

STRING: 155864.Z4594

Promotions

Transmembrane Protein Questionnaire with Gifts

Email: [email protected]
Distributors Worldwide

Service

Phage Display Service

Antibody Service

Protein Service

Gene Synthesis Service

Oligo Synthesis Service

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Call us

301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

[email protected]

Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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degS Antibody

Product Details

Related Products

Customer Reviews and Q&A

Target Background