Drs Antibody

Datasheet

Code	CSB-PA331379XA01DLU
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Product Details

Full Product Name

Rabbit anti-Drosophila melanogaster (Fruit fly) Drs Polyclonal antibody

Uniprot No.

P41964

Target Names

Drs

Alternative Names

Drs antibody; CRP antibody; CG10810Drosomycin antibody; Cysteine-rich peptide antibody

Raised in

Rabbit

Species Reactivity

Drosophila melanogaster (Fruit fly)

Immunogen

Recombinant Drosophila melanogaster (Fruit fly) Drs protein

Immunogen Species

Drosophila melanogaster (Fruit fly)

Conjugate

Non-conjugated

Clonality

Polyclonal

Isotype

IgG

Purification Method

Antigen Affinity Purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form

Liquid

Tested Applications

ELISA, WB (ensure identification of antigen)

Protocols

ELISA Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Value-added Deliverables

① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);

Quality Guarantee

① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;

Lead Time

Made-to-order (14-16 weeks)

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Target Background

Function

Possesses antifungal activity and is active against a relatively broad spectrum of filamentous fungi. It inhibits spore germination at high concentrations and at low concentrations delays growth of hyphae which subsequently exhibit abnormal morphology. Spz C-106 in the hemolymph controls expression of the antifungal peptide by acting as a ligand of Tl and inducing an intracellular signaling pathway. Part of a psh-dependent Toll pathway, which may function in activating the systematic immune response in response to localized melanization of the tracheal system.

Gene References into Functions

in this study drosomycin is identified as the target of miR-964 PMID: 28823799
In 14-3-3epsilon mutants, there was a reduced release of the anti-microbial peptide Drosomycin into the haemolymph PMID: 21670199
identified five cationic residues (R6, K8, R20, R21 and K38) whose alterations significantly affected the antifungal activity PMID: 20420852
Expression of the AMP gene drosomycin (a Toll target) was blocked when expression of the Toll ligand Spatzle was knocked down in haemocytes. PMID: 19934223
Similarity in sequence, structure and biological activity suggests that drosomycin and some defensin molecules from plants and fungi could originate from a common ancestor. PMID: 19754735

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Subcellular Location

Secreted.

Tissue Specificity

Synthesized in the fat body and is secreted into the blood. In hemolymph 6 hours after immune challenge, levels of expression increase for first 24 hours and persist for the following three weeks. In larvae, expressed in the visceral branches and posterio

Database Links

KEGG: dme:Dmel_CG10810

STRING: 7227.FBpp0072935

UniGene: Dm.14479

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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

[email protected]

Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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Drs Antibody

Product Details

Related Products

Customer Reviews and Q&A

Target Background