dsh Antibody

1. a likely direct interaction between Dishevelled and Fritz, is reported. PMID: 28258110
2. Exon junction complex (EJC) activity is indispensable for Wg signaling by maintaining an appropriate level of Dsh protein for Wg ligand reception in Drosophila. Genetic and biochemical experiments demonstrate that Dlg1 protein acts independently from its role in cell polarity to protect Dsh protein from lysosomal degradation. PMID: 27536874
3. Klp64D forms a complex with Dsh and shows functional interaction. PMID: 25063455
4. The mechanism by which Wingless signalling is able to downregulate Notch is by promoting its ligand-independent traffic to a compartment where it is degraded and that this activity depends on Dishevelled. PMID: 20495361
5. co-expression experiments reveal that APC displaces Dishevelled from Axin assemblies, promoting degradasome over signalosome formation in the absence of Wnts PMID: 22645652
6. Mutations that compromise a direct interaction between Dishevelled and Notch reduce the efficacy of repression. PMID: 22736244
7. while many Ser/Thr and Tyr residues are indeed phosphorylated in vivo, strikingly most of these phosphorylation events are not critical for Dsh function with the exception of DshY473 PMID: 21963539
8. This result implies that Dishevelled has the potential to act as a "natural" dominant-negative, binding to the polymerization interface of Axin's DIX domain to interfere with its self-assembly PMID: 21245303
9. Dsh-Lgl interaction contributes to epidermal tissue morphogenesis. PMID: 20736316
10. Results describe a Frizzled-Dishevelled-NuMA/Mud pathway that orients division from Drosophila to vertebrates. PMID: 21074723
11. dAbl positively regulates the Fz/Dishevelled (Dsh) PCP pathway without affecting canonical Wnt/Wg-Fz signaling PMID: 20837657
12. Dishevelled signals through LRP5/6 in human cells and Drosophila embryos. PMID: 20388731
13. Pk causes dsh to have an asymmetric localization in the cytoplasm of Drosophila. PMID: 12015986
14. mutational analysis of dishevelled in Drosophila defines novel domains in the dishevelled protein as well as novel suppressing alleles of axin PMID: 12072470
15. interaction with naked cuticle antagonizing Wnt signaling PMID: 12354775
16. Genetic interactions and epistasis analysis suggest that frizzled, dishevelled, and fat act together in the long-range propagation of polarity signals in the eye and wing. PMID: 12479810
17. Data show that Strabismus becomes asymmetrically localised to the proximal edge of cells, then binds directly to Dishevelled and Prickle and is able to recruit them to membranes. PMID: 12756182
18. Binding of Dishevelled to the ankyrin-repeat protein Diego promotes Frizzled signalling. PMID: 15937478
19. Lgl associates with Dishevelled, an essential mediator of Wnt signalling, and that Dishevelled regulates the localization of Lgl in Xenopus ectoderm and Drosophila follicular epithelium PMID: 16251968
20. the interaction of Fz or Dsh with other proteins could modulate the signal transduction via interactions between frizzled and dishevelled PMID: 18065209
21. These results suggest that direct interaction between Fz and Dsh is stabilized by a pH and charge-dependent interaction of the DEP domain with phospholipids. PMID: 19234454

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KEGG: dme:Dmel_CG18361

STRING: 7227.FBpp0073310

UniGene: Dm.2927