dsx Antibody

1. The sex determination genes fruitless and doublesex, and a sex-specific P1-DN1 neuronal feedback govern the interaction between sleep and sexual behavior. PMID: 28754889
2. Sex differences in Drosophila somatic gene expression controlled by variation and regulation by doublesex have been scrutinized. PMID: 27172187
3. doublesex is required in the TN1A neurons during development to increase the density of the TN1A arbors that interact with dendrites of the hg1 motoneuron. PMID: 27326931
4. DSX targets include transcription factors and signaling pathway components providing for direct and indirect regulation of sex-biased expression PMID: 25535918
5. Silencing doublesex expressing neurons makes females unreceptive to courtship and copulation. PMID: 24991959
6. These results reveal a process that builds, via dsx(M) and social experience, the potential for a more flexible sexual behavior, which could be evolutionarily conserved as dsx-related genes that function in sexual development are found throughout the animal kingdom. PMID: 24439379
7. The respective sex-specific product of the gene doublesex promotes programmed cell death of terminal neuroblasts in females, and is needed for their survival, but not proliferation, in males. PMID: 23533181
8. These results suggest that the foreleg provides a unique opportunity for examining the context-dependent functions of DSX. PMID: 23240029
9. dsx protein is required to induce female postmating behavioral responses PMID: 22658598
10. Dsx is a transcriptional target of Abdominal-B, and its regulation sculpts sex-specific abdomen morphology. PMID: 22488883
11. This chapter reviews the role of doublesex and the neurons that express it in the regulation of courtship behavior. PMID: 21906537
12. precise spatial regulation of dsx is essential for sex comb development and has played a key role in the origin and evolution of this structure PMID: 21886483
13. Twenty-three genes are associated with both an in vivo peak in DSX binding and an optimal DSX-binding sequence, and thus are almost certainly direct DSX targets. PMID: 21652649
14. Female-specific doublesex isoform regulates pleiotropic transcription factors to pattern genital development. PMID: 21343364
15. Tissue-specific aspects of sexual development are jointly specified by post-transcriptional control by Sxl and by the transcriptional controls of dsx and fru expression. PMID: 20454565
16. Disrupting doublesex gene neuronal function has profound effects on male sexual behavior; dsx-positive neurons are involved in pre- to post-copulatory female reproductive behaviors. PMID: 20305646
17. Only in males do gustatory receptor neuron axons project across the midline of the ventral nerve cord. We show that fruitless and doublesex both contribute to establishing this sexual dimorphism. PMID: 20040498
18. Purine-rich exon sequences are not necessarily splicing enhancer sequence in the dystrophin gene. PMID: 11781497
19. involved in sex-specific gene regulation PMID: 12198117
20. IX and DSX(F) function in a complex, in which IX acts as a transcriptional co-factor for the DNA-binding DSX(F). PMID: 12361959
21. crystal structure PMID: 15213406
22. Study results raise the possibility that a functional association between ix and dsx gene products existed before the origin of the bifunctional dsx gene used in insect sex determination. PMID: 15645316
23. doublesex dimerization is mediated by a cryptic ubiquitin-associated domain fold and may have a role in the regulation of sexual dimorphism PMID: 16049008
24. There are molecular links between the structure of the DM domain of dsx and its function in the regulation of sexual dimorphism. PMID: 16382145
25. Doublesex could contribute to regulation of female-specific expression of the Ochlerotatus atropalpus Hex-1.2 gene. PMID: 16756549
26. Without the male isoform of dsx the determination of a male-specific central nervous system and thus a full complement of male behaviors are not realized. PMID: 17716899
27. doublesex and fruitless genes are both required in thoracic neurons to generate normal male lovesongs. PMID: 17925211
28. The continuous expression of DSX(M) in cells contacting the germline suggests an ongoing short-range influence of the somatic sex determination pathway on germ cell development PMID: 17935627
29. Doublesex has a role in regulation of sexual dimorphism in Drosophila melanogaster through a female-specific domain PMID: 18184648
30. role of fruitless and doublesex in establishing sexually dimorphic features of neural circuitry and behavior [review] PMID: 19541474

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KEGG: dme:Dmel_CG11094

STRING: 7227.FBpp0303107

UniGene: Dm.3308