cher Antibody

Datasheet

Code	CSB-PA913482XA01DLU
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Product Details
Customer Reviews and Q&A
Target Background

Product Details

Full Product Name

Rabbit anti-Drosophila melanogaster (Fruit fly) cher Polyclonal antibody

Uniprot No.

Q9VEN1

Target Names

cher

Alternative Names

cher antibody; cheerio antibody; sko antibody; CG3937Filamin-A antibody; FLN-A antibody; Actin-binding protein 280 antibody; ABP-280 antibody; Filamin-1 antibody; Filamin1 antibody

Raised in

Rabbit

Species Reactivity

Drosophila melanogaster (Fruit fly)

Immunogen

Recombinant Drosophila melanogaster (Fruit fly) cher protein

Immunogen Species

Drosophila melanogaster (Fruit fly)

Conjugate

Non-conjugated

Clonality

Polyclonal

Isotype

IgG

Purification Method

Antigen Affinity Purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form

Liquid

Tested Applications

ELISA, WB (ensure identification of antigen)

Protocols

ELISA Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Value-added Deliverables

① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);

Quality Guarantee

① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;

Lead Time

Made-to-order (14-16 weeks)

Customer Reviews and Q&A

■ Customer Reviews

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Target Background

Function

Involved in the germline ring canal formation. May tether actin microfilament within the ovarian ring canal to the cell membrane. Contributes to actin microfilaments organization.

Gene References into Functions

FLN90, an isoform of the Drosophila ortholog Filamin/cheerio that lacks the actin-binding domain, is here shown to govern the growth of postsynaptic membrane folds and the composition of glutamate receptor clusters at the larval neuromuscular junction. PMID: 27914199
Here we show using Drosophila indirect flight muscle that the filamin ortholog Cheerio in conjunction with the giant elastic protein titin plays a crucial role in keeping thin filaments stably anchored at the Z-disc. We identify the filamin domains required for interaction with the titin ortholog Sallimus, and we demonstrate a genetic interaction of filamin with titin and actin. PMID: 28732005
study identifies Cher as a new target of JNK signaling that links cytoskeleton dynamics to tumor progression. PMID: 23239028
Filamin is required for ovarian follicle cell motility during oogenesis. PMID: 12885568

Subcellular Location

Cytoplasm, cytoskeleton. Cell membrane. Note=Localizes to intercellular bridges corresponding to ring canals that connect cytoplasm of nurse cells to the developing oocyte. Localizes to nurse cell plasma membranes. Detected in both the inner and outer rims of the ring canal.

Protein Families

Filamin family

Tissue Specificity

Germline-specific in females (at protein level). Expressed in ovary.

Database Links

KEGG: dme:Dmel_CG3937

UniGene: Dm.6964

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