hda-1 Antibody

Datasheet

Code	CSB-PA010235XA01CXY
Size	Enquire
Have Questions?	Leave a Message or Start an on-line Chat

Product Details
Related Products
Customer Reviews and Q&A
Target Background

Product Details

Full Product Name

Rabbit anti-Caenorhabditis elegans hda-1 Polyclonal antibody

Uniprot No.

O17695

Target Names

hda-1

Alternative Names

hda-1 antibody; C53A5.3 antibody; Histone deacetylase 1 antibody; EC 3.5.1.98 antibody

Raised in

Rabbit

Species Reactivity

Caenorhabditis elegans

Immunogen

Recombinant Caenorhabditis elegans hda-1 protein

Immunogen Species

Caenorhabditis elegans

Conjugate

Non-conjugated

Clonality

Polyclonal

Isotype

IgG

Purification Method

Antigen Affinity Purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form

Liquid

Tested Applications

ELISA, WB (ensure identification of antigen)

Protocols

ELISA Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Value-added Deliverables

① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);

Quality Guarantee

① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;

Lead Time

Made-to-order (14-16 weeks)

Customer Reviews and Q&A

■ Customer Reviews

There are currently no reviews for this product.

Submit a Review here

Target Background

Function

Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression. Plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Involved in the endoderm determination possibly by repressing end-1 expression. Also involved in vulval development, possibly by repressing lag-2 expression. Required during mitochondrial stress for the activation of genes involved in the mitochondrial unfolded protein response (mtUPR), in concert with homeobox protein dve-1. Promotes normal hermaphrodite (XX) development, in concert with zinc finger protein tra-4 and nasp-1, perhaps as components of a complex. Plays a role in the regulation of longevity and mtUPR-associated innate immunity. In association with akir-1, plays a role in regulating the transcription of antimicrobial peptide genes in response to fungal infection.

Gene References into Functions

We further show that G1 arrest is necessary for the histone deacetylase HDA-1, a key regulator of differentiation, to promote pro-invasive gene expression and invadopodia formation. PMID: 26506306
hda-1 target genes revealed that fos-1 acts downstream of hda-1 in vulval cells, whereas egl-43 and nhr-67 mediate hda-1 function in the gonadal anchor cell. PMID: 23797102
HDAC behaves as a co-repressor modulating FOS-1-mediated transcriptional regulation PMID: 23437011
Theses studies define a new role for HDA-1 in nervous system development, and provide the first evidence for HDAC function in regulating neuronal axon guidance. PMID: 16313898

Subcellular Location

Nucleus. Cytoplasm. Chromosome. Note=Except in the germ line where it is also cytoplasmic.

Protein Families

Histone deacetylase family, HD type 1 subfamily

Tissue Specificity

Ubiquitously expressed throughout embryonic and postembryonic development.

Database Links

KEGG: cel:CELE_C53A5.3

STRING: 6239.C53A5.3.2

UniGene: Cel.17341

Promotions

Transmembrane Protein Questionnaire with Gifts

Email: [email protected]
Distributors Worldwide

Service

Phage Display Service

Antibody Service

Protein Service

Gene Synthesis Service

Oligo Synthesis Service

Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

Call us

301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

[email protected]

Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

Join us with

Subscribe newsletter

Leave a message

Message

Product >> Product Name：
Product >> Code：
Name： *
Email： *
Company/Organization：
Phone：
Since emails may get flagged by spam filters occasionally, we recommend leaving your phone number as a precaution. Your information is safe with us.
Question/Comment： *
Your Region： *
I'd like to receive email newsletters from Cusabio

Yes

No
How do you know CUSABIO?

Email

Distributor

Search engine

Advertisement

Others
CAPTCHA verification：

hda-1 Antibody

Product Details

Related Products

Customer Reviews and Q&A

Target Background