Hrs Antibody

1. The present report is devoted to the clarification and detailing of the Hrs effect on D/V, as well as on A/P borders of the imaginal wing disc compartments in Drosophila melanogaster. PMID: 27169237
2. Hrs is dispensable for cytokinesis. Finally, it was found that although Drosophila Hrs does not localize at acrosome, the other endosomal markers--Rab4, Rab7, and Rab11--are detected at the organelle. PMID: 26591063
3. Drosophila epithelia lacking Hrs and Stam, accumulate Notch and Dome in endosomes, maintain normal apico-basal polarity and proliferation control and do not show ectopic Notch signaling activation. PMID: 24718108
4. Hrs mediates Smo trafficking in the late endosome by not only promoting Smo ubiquitination but also blocking Smo phosphorylation. PMID: 24244405
5. these data support a model in which Ubpy plays a dual role in both cargo deubiquitylation and the ESCRT-0 subunit Hrs stability during development. PMID: 24574010
6. Hrs protein is involved in the formation of the D/V boundary of the wing imaginal disk and suggested a new role in wing vein refinement for the Hrs gene PMID: 23113331
7. show that the endosomal proteins Myopic (Mop) and Hepatocyte growth factor-regulated tyrosine kinase substrate (Hrs) are required for the activation of the Toll signaling pathway. PMID: 20404143
8. PtdIns(3)P specifically induces the membrane penetration of the FYVE domain of HRS protein and increases it membrane resonance time causing local conformational changes PMID: 12006563
9. intracellular accumulation of receptors in Hrs mutant cells could be due to defective sorting towards lysosomal degradation or to defective post-endocytic retention in endosomes PMID: 14608370

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KEGG: dme:Dmel_CG2903

STRING: 7227.FBpp0088692

UniGene: Dm.274