HXK2 Antibody

1. Taken together, we have proposed a working model to describe how Vma3p protects cells against apoptosis through the regulation of HXK2 expression. PMID: 28899778
2. Deletion of AIF1 in hxk2Delta cells enhances survival after induction of apoptosis with both H2O2 and acetic acid, rescues the reduction of both growth rate and cell size, abrogates both H2O2 and acetic acid-induced ROS accumulation and decreases cell death, suggesting that Aif1 might be involved in both H2O2 and acetic acid-induced cell death in hxk2Delta cells. PMID: 26895787
3. Hxk2 constitutes an intracellular glucose sensor that operates by changing its conformation in response to cytoplasmic glucose levels that regulate its interaction with Mig1 and thus its recruitment to the repressor complex of theSUC2promoter. PMID: 26865637
4. Ymr291w/Tda1 is likely to contribute to glucose signaling in S. cerevisiae on the level of ScHxk2-S15 phosphorylation in a situation of limited external glucose availability PMID: 25593311
5. a functional link between Hxk2, Reg1, and Snf1 signaling, which involves the regulation of Hxk2 nucleocytoplasmic shuttling by phosphorylation-dephosphorylation of serine 14. PMID: 23066030
6. Deletion of YMR291W/TDA1 resulted in the absence of the Hxk2 phosphomonomer, indicating an indispensable role of the corresponding protein in Hxk2 phosphorylation. PMID: 22289182
7. Data demonstrated that Hxk2(wca) mutant maintained full regulatory function because the glucose-repression signalling of the wild-type machinery is maintained. PMID: 20815814
8. A model that explains how low-glucose levels repress HXK2 gene expression. PMID: 16528100
9. Overproduction of Hap4p behaved similar to the wild-type strain, deletion of hxk2 resulted in a very different fermentative capacity profile. PMID: 18179578
10. Data suggest that conformational transition of hexokinase B is reversible, and irreversibility is due to aggregation, as a major cause. PMID: 18715685
11. Hxk2 phosphorylation at serine 14 promotes Hxk2 export by facilitating the association of Hxk2 with Xpo1. PMID: 19525230
12. The trehalose pathway is shown to regulate the mitochondrial enzymatic content in Saccharomyces cerevisiae. PMID: 19620241

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KEGG: sce:YGL253W

STRING: 4932.YGL253W