HYR1 Antibody

Code CSB-PA781321XA01CZD
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Product Details

Full Product Name
Rabbit anti-Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast) HYR1 Polyclonal antibody
Uniprot No.
Target Names
HYR1
Alternative Names
HYR1 antibody; GPX1 antibody; CAALFM_C113450WA antibody; CaO19.12440 antibody; CaO19.4975 antibody; Hyphally regulated cell wall protein 1 antibody; Adhesin-like protein HYR1 antibody
Raised in
Rabbit
Species Reactivity
Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Immunogen
Recombinant Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast) HYR1 protein
Immunogen Species
Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Conjugate
Non-conjugated
Clonality
Polyclonal
Isotype
IgG
Purification Method
Antigen Affinity Purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Tested Applications
ELISA, WB (ensure identification of antigen)
Protocols
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Value-added Deliverables
① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);
Quality Guarantee
① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;
Lead Time
Made-to-order (14-16 weeks)

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Target Background

Function
GPI-anchored hyphal cell wall protein required for hyphal growth and virulence. Involved in innate immune cell evasion through confering resistance to neutrophil killing. Binds kininogen, the proteinaceous kinin precursor, and contributes to trigger the kinin-forming cascade on the cell surface. Production of kinins is often involved in the human host defense against microbial infections.
Gene References into Functions
  1. Overexpression of HYR1, but not HWP1, significantly rescued this biofilm phenotype PMID: 21283544
  2. Hyr1 is an important virulence factor for Candida albicans, mediating resistance to phagocyte killing. PMID: 20415594
Subcellular Location
Secreted, cell wall. Membrane; Lipid-anchor, GPI-anchor.
Protein Families
HYR1/IFF family
Database Links
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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)
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Address
7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA
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