KAP114 Antibody

Code CSB-PA346424XA01SVG
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Product Details

Full Product Name
Rabbit anti-Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) KAP114 Polyclonal antibody
Uniprot No.
Target Names
KAP114
Alternative Names
KAP114 antibody; YGL241W antibody; HRC1004Importin subunit beta-5 antibody; 114 kDa karyopherin antibody; Karyopherin subunit beta-5 antibody; Karyopherin-114 antibody
Raised in
Rabbit
Species Reactivity
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Immunogen
Recombinant Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) KAP114 protein
Immunogen Species
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Conjugate
Non-conjugated
Clonality
Polyclonal
Isotype
IgG
Purification Method
Antigen Affinity Purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Tested Applications
ELISA, WB (ensure identification of antigen)
Protocols
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Value-added Deliverables
① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);
Quality Guarantee
① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;
Lead Time
Made-to-order (14-16 weeks)

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Target Background

Function
Required for nuclear protein import and mediates docking of import substrate to distinct nucleoporins. Serves a receptor for nuclear localization signals. Mediates the nuclear import of TATA-binding protein (TBP) and of histones H2A and H2B.
Gene References into Functions
  1. It is proposed that sumoylation occurs at the site of Kap114 cargo function and that small ubiquitin-related modifier is a cargo release factor involved in intranuclear targeting. PMID: 22562154
  2. The KAP114 protein functions is in a parallel import pathway for H2A and H2B. PMID: 15679097
  3. Kap114p, responsible for the nuclear import of histones H2A and H2B, modulates the deposition of histones H2A and H2B by the histone chaperone Nap1p. PMID: 15713633
  4. TFIIB nuclear import is mediated by Kap114p PMID: 15888545
Subcellular Location
Cytoplasm. Nucleus, nuclear pore complex.
Protein Families
Importin beta family
Database Links

KEGG: sce:YGL241W

STRING: 4932.YGL241W

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