Product Details

Full Product Name

Rabbit anti-Arabidopsis thaliana (Mouse-ear cress) KAN1 Polyclonal antibody

Uniprot No.

Q93WJ9

Target Names

KAN1

Alternative Names

KAN1 antibody; KAN antibody; At5g16560 antibody; MQK4.31 antibody; Transcription repressor KAN1 antibody; Protein KANADI 1 antibody

Raised in

Rabbit

Species Reactivity

Arabidopsis thaliana

Immunogen

Recombinant Arabidopsis thaliana KAN1 protein

Immunogen Species

Arabidopsis thaliana (Mouse-ear cress)

Conjugate

Non-conjugated

Clonality

Polyclonal

Isotype

IgG

Purification Method

Antigen Affinity Purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form

Liquid

Tested Applications

ELISA, WB (ensure identification of antigen)

Protocols

ELISA Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Value-added Deliverables

① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);

Quality Guarantee

① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;

Lead Time

Made-to-order (14-16 weeks)

Target Background

Function

Transcriptional repressor that regulates lateral organ polarity. Promotes lateral organ abaxial identity by repressing the adaxial regulator ASYMMETRIC LEAVES2 (AS2) in abaxial cells. Required for abaxial identity in both leaves and carpels. Functions with KAN2 in the specification of polarity of the ovule outer integument. Regulates cambium activity by repressing the auxin efflux carrier PIN1. Plays a role in lateral root formation and development.

Gene References into Functions

KAN1 acts upstream of several genes encoding auxin biosynthetic enzymes.KAN1 plays a role in shade-avoidance responses.KAN1 activity suppresses auxin synthesis and signaling. PMID: 26246448
HD-ZIPIII and KANADI regulate tissue-specific transcription factors involved in subsidiary developmental decisions, nearly all major hormone pathways, and new actors (such as indeterminate domain4) in the ad/abaxial regulatory network. PMID: 24076978
HD-ZIPIII and KANADI transcription factors pattern auxin accumulation and responsiveness in the embryo. PMID: 24464295
a set of potential direct target genes of KAN1, were identified. PMID: 24155946
Leaf polarity is established by the opposed actions of HD-ZIPIII and KANADI transcription factors. PMID: 22578006
Class III HD-ZIP and KANADI transcription factors control cambium activity: KANADI proteins by acting on auxin transport, and Class III HD-ZIP proteins by promoting axial cell elongation and xylem differentiation. PMID: 20179097
As KANADI is not required for either ETT or ARF4 transcription, and their overexpression cannot rescue kanadi mutants, cooperative activity is implied. PMID: 16199616
KAN1 acts as a transcriptional repressor and that mutually repressive interactions between KAN1 and AS2 contribute to the establishment of adaxial-abaxial polarity in plants PMID: 18849474

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Subcellular Location

Nucleus.

Tissue Specificity

Expressed in developing phloem and lateral root.

Database Links

KEGG: ath:AT5G16560

STRING: 3702.AT5G16560.1

UniGene: At.6466

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KAN1 Antibody

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