pal-1 Antibody

Code CSB-PA341575XA01CXY
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Product Details

Full Product Name
Rabbit anti-Caenorhabditis elegans pal-1 Polyclonal antibody
Uniprot No.
Target Names
pal-1
Alternative Names
pal-1 antibody; ceh-3 antibody; C38D4.6 antibody; Homeobox protein pal-1 antibody; Caudal homolog 1 antibody; Homeobox protein ceh-3 antibody; Posterior alae in males protein 1 antibody
Raised in
Rabbit
Species Reactivity
Caenorhabditis elegans
Immunogen
Recombinant Caenorhabditis elegans pal-1 protein
Immunogen Species
Caenorhabditis elegans
Conjugate
Non-conjugated
Clonality
Polyclonal
Isotype
IgG
Purification Method
Antigen Affinity Purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Tested Applications
ELISA, WB (ensure identification of antigen)
Protocols
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Value-added Deliverables
① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);
Quality Guarantee
① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;
Lead Time
Made-to-order (14-16 weeks)

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Target Background

Function
Transcriptional activator. Interacts with promoter regions for tbx-8.9, tbx-9, elt-1, hnd-1, scrt-1, and vab-7 genes. Binds the sequence ATTTATGAC. Binds to the enhancer region of the hlh-1 gene promoter during embryonic body wall muscle development. Activates the gene for mab-5 in embryo development. Necessary for vab-7 expression in C blastomeres in the posterior of embryos. Required for posterior V6 neuroectoblast cell fate specification during postembryonic neurogenesis (patterning) which generates the characteristic ray lineage during male tail development. Binds to ced-3 promoter and activated expression which is crucial for tail-spike cell death. Has a role in E cell specification in endoderm development and body wall muscle development.
Gene References into Functions
  1. a developmental switch in the translational control of C. elegans PAL-1 is mediated by the STAR/Maxi-KH domain protein GLD-1 PMID: 15201219
  2. PAL-1 specifies the identity and maintains the development of the multipotent C blastomere lineage in the C. elegans embryo. PMID: 15772128
Subcellular Location
Nucleus. Chromosome, centromere, kinetochore. Chromosome. Note=Localized to condensed chromosomes.
Protein Families
Caudal homeobox family
Tissue Specificity
Blastomeres. Embryo. Oocytes.
Database Links
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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)
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Address
7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA
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