Pde4b Antibody

1. PDE4B mediates a crucial PKA-dependent feedback that controls beta1 adrenergic receptor-dependent cAMP signals in a restricted subsarcolemmal domain. PMID: 24413164
2. Upregulated PDE4 expression during cholestatic liver injury plays a potential pathogenic role in the development of inflammation and fibrosis. PMID: 23887098
3. Acutely after spinal cord injury, PDE4B is localized to activated microglia and is absent in uninjured spinal cord or inactive microglia. PMID: 22865690
4. PDE3a, PDE4b and PDE4d isoforms mRNAs were highly expressed in the whole cervical ganglia with no modulation by hypoxia. PMID: 23080174
5. This study identified a specific type IV phosphodiesterase gene, PDE4B3, the first cAMP-specific phosphodiesterase to be associated with LTP. PMID: 12617967
6. LTP-specific translational, but not transcriptional regulation of PDE4B3 within first 8 h after tetanization. Spatio-temporal changes of PDE4B proteins and cAMP that is LTP-specific. PMID: 15026126
7. From these results, we conclude that either the changes in PDE4B are due to modulation of pre-existing mRNA, or that the protein is specifically translocated to activated synaptic structures. PMID: 15829230
8. Pde4B, a cAMP-specific phosphodiesterase, is upregulated by Abeta and results in an increased production of TNF-alpha PMID: 15993984
9. PDE4B2 plays a negative feedback role in adrenergic/cAMP signaling in the pineal gland. PMID: 17204557
10. the activation of the PDE4B2 gene plays a role in the neuroinflammatory process in experimental autoimmune encephalomyelitis rats PMID: 17917586
11. Increased PDE4 activity, specifically phosphodiesterase 4B4 activity, reduces beta-adrenergic signaling in the kidney and contributes to salt-sensitive hypertension in the Dahl SS rat. PMID: 18227403
12. These results demonstrate for the first time that spinal cord glial cells express PDE4 subtypes and that the PDE4 inhibitor rolipram protects oligodendrocytes from secondary cell death following contusive SCI. PMID: 18455876
13. Increased phosphodiesterase 3A/4B expression after angioplasty and the effect on VASP phosphorylation. PMID: 18571642
14. Adrenergic-cyclic AMP induction of Pde4b in the pineal gland at night results in accumulation of the Pde4b2 splice variant. PMID: 17204557
15. Expression of Pde4b in the pineal gland is more than 6-fold higher than in other tissues, except lung. PMID: 17204557
16. Expression of Pde4b in the pineal gland is regulated by a neural-cyclic AMP system which produces a marked increase in transcript and protein at night. PMID: 17204557

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KEGG: rno:24626

STRING: 10116.ENSRNOP00000007738

UniGene: Rn.37733