PGRP-SA Antibody

Datasheet

Code	CSB-PA895215XA01DLU
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Product Details

Full Product Name

Rabbit anti-Drosophila melanogaster (Fruit fly) PGRP-SA Polyclonal antibody

Uniprot No.

Q9VYX7

Target Names

PGRP-SA

Alternative Names

PGRP-SA antibody; seml antibody; CG11709 antibody; Peptidoglycan-recognition protein SA antibody; EC 3.4.17.13 antibody; Protein semmelweis antibody

Raised in

Rabbit

Species Reactivity

Drosophila melanogaster (Fruit fly)

Immunogen

Recombinant Drosophila melanogaster (Fruit fly) PGRP-SA protein

Immunogen Species

Drosophila melanogaster (Fruit fly)

Conjugate

Non-conjugated

Clonality

Polyclonal

Isotype

IgG

Purification Method

Antigen Affinity Purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form

Liquid

Tested Applications

ELISA, WB (ensure identification of antigen)

Protocols

ELISA Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Value-added Deliverables

① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);

Quality Guarantee

① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;

Lead Time

Made-to-order (14-16 weeks)

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Target Background

Function

Peptidoglycan-recognition protein that plays a key role in innate immunity by binding to peptidoglycans (PGN) of Gram-positive bacteria and activating the Toll pathway upstream of spz activating enzyme SPE. Has no activity against Gram-negative bacteria and fungi. Shows some partial redundancy with PRPGP-SD in Gram-positive bacteria recognition. May act by forming a complex with GNBP1 that activates the proteolytic cleavage of Spatzle and the subsequent activation of Toll pathway. Binds to diaminopimelic acid-type tetrapeptide PGN (DAP-type PGN) and lysine-type PGN (Lys-type PGN). Has some L,D-carboxypeptidase activity for DAP-type PGN, which are specific to prokaryotes, but not for Lys-type PGN.

Gene References into Functions

Wall teichoic acids of Staphylococcus aureus limit recognition by the drosophila peptidoglycan recognition protein-SA to promote pathogenicity. PMID: 22144903
results demonstrate that GNBP1 and PGRP-SA can jointly activate the Toll pathway PMID: 14684822
PGRP-SA contains a peptidoglycan docking groove and unusual L,D-carboxypeptidase activity PMID: 15361936
GNBP1 presents a processed form of peptidoglycan for sensing by PGRP-SA and that a tripartite interaction between these proteins and peptidoglycan is essential for downstream signaling. PMID: 17024181

Subcellular Location

Secreted. Note=Secreted in hemolymph.

Protein Families

N-acetylmuramoyl-L-alanine amidase 2 family

Tissue Specificity

In larvae, it is expressed in fat body. Also expressed in uninduced hemocytes and mbn-2 cells.

Database Links

KEGG: dme:Dmel_CG11709

STRING: 7227.FBpp0073358

UniGene: Dm.14186

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Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

Call us

301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

[email protected]

Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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PGRP-SA Antibody

Product Details

Related Products

Customer Reviews and Q&A

Target Background