PGRP-SD Antibody

Datasheet

Code	CSB-PA893320XA01DLU
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Product Details

Full Product Name

Rabbit anti-Drosophila melanogaster (Fruit fly) PGRP-SD Polyclonal antibody

Uniprot No.

Q9VS97

Target Names

PGRP-SD

Alternative Names

PGRP-SD antibody; CG7496 antibody; Peptidoglycan-recognition protein SD antibody

Raised in

Rabbit

Species Reactivity

Drosophila melanogaster (Fruit fly)

Immunogen

Recombinant Drosophila melanogaster (Fruit fly) PGRP-SD protein

Immunogen Species

Drosophila melanogaster (Fruit fly)

Conjugate

Non-conjugated

Clonality

Polyclonal

Isotype

IgG

Purification Method

Antigen Affinity Purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form

Liquid

Tested Applications

ELISA, WB (ensure identification of antigen)

Protocols

ELISA Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Value-added Deliverables

① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);

Quality Guarantee

① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;

Lead Time

Made-to-order (14-16 weeks)

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Target Background

Function

Peptidoglycan-recognition protein that plays a key role in innate immunity by binding to peptidoglycans (PGN) of Gram-positive bacteria and activating the Toll pathway. Has no activity against on Gram-negative bacteria and fungi. Shows some partial redundancy with PRPGP-SA in Gram-positive bacteria recognition. May act by activating the proteolytic cleavage of Spatzle and the subsequent activation of Toll pathway. Recognizes S.aureus PGN.

Gene References into Functions

These data reveal that Drosophila PGRP-SD functions as an extracellular receptor similar to mammalian CD14 PMID: 27851910
crystal structure of PGRP-SD at 1.5A resolution; findings suggest a diaminopimelic acid (DAP) specificity for PGRP-SD; hypothesis is that role of PGRP-SD is recognition of DAP-type PGNs responsible for activation of Toll pathway by Gram-negative bacteria PMID: 18304640
interplay between the binding affinities of different PGRPs provides sufficient flexibility for the recognition of the highly diverse Gram-positive peptidoglycan PMID: 18697931

Subcellular Location

Secreted.

Protein Families

N-acetylmuramoyl-L-alanine amidase 2 family

Tissue Specificity

In larvae, it is mainly expressed in fat body. Also expressed in uninduced hemocytes and mbn-2 cells.

Database Links

KEGG: dme:Dmel_CG7496

STRING: 7227.FBpp0076519

UniGene: Dm.33934

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Service

Phage Display Service

Antibody Service

Protein Service

Gene Synthesis Service

Oligo Synthesis Service

Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

Call us

301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

[email protected]

Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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PGRP-SD Antibody

Product Details

Related Products

Customer Reviews and Q&A

Target Background