Rad51 Antibody

1. Swi5-Sfr1 (S5S1) stimulates Rad51-mediated homologous recombination. PMID: 30297419
2. Rad51 negatively regulates Netrin-1 signaling by modulating the expression of Unc5s in developing motor cortex. PMID: 28057929
3. RT-PCR and immunobloting data show that inhibitory effect of sodium butyrate takes place at the level of Rad51 and XRCC5 gene transcription and the content of Rad51 and Ku80 proteins. PMID: 30188106
4. Data show that the expression of miR-193b-3p and Rad51 was altered in in response to low-dose irradiation (LDIR) exposure. PMID: 27225532
5. The anti-recombinase activity of BLM is of general importance for normal retention of RAD51 at DNA double strand break sites and regulation of homologous recombination. PMID: 28912125
6. Our results thus help establish the functional relevance of the trimeric RAD51-SWI5-SFR1 complex and provide insights into the mechanistic underpinnings of homology-directed DNA repair in mammalian cells. PMID: 27131790
7. Unlike directly induced DSBs, secondary DSBs were not efficiently repaired, although Rad51 and 53BP1 were recruited to these sites. H2AX was dramatically stabilized in response to DSBs directly caused by gamma-rays, enabling gammaH2AX foci formation and DSB repair, whereas H2AX was barely stabilized in response to secondary DSBs, in which gammaH2AX foci were small and DSBs were not efficiently repaired PMID: 27251002
8. Rad51 repaired DNA damage. PMID: 24991985
9. An antimorphic mRad51 mutation, when present in heterozygous condition over wild-type, displays defects in non-replication-associated DNA repair and not in replication-associated repair. PMID: 25463395
10. BRCA2-mediated sequestration of nuclear RAD51 serves to prevent inappropriate DNA interactions. PMID: 25488918
11. increased Rad51 concentration and homology length interact synergistically to promote 3' extension, presumably as a result of enhanced Brca2-mediated Rad51 polymerization PMID: 24583581
12. Results suggest that cellular levels of Brca2 and Rad51 are mutually dependent on each other, and that low levels of these proteins provide selective pressure for reduction of p53, which permits cell growth PMID: 24210700
13. FBH1 restraining RAD51 DNA binding under unperturbed growth conditions to prevent unwanted or unscheduled DNA recombination. PMID: 24108124
14. HELQ interacts directly with the RAD51 paralogue complex BCDX2 and functions in parallel to the Fanconi anaemia pathway to promote efficient homologous recombination at damaged replication forks PMID: 24005329
15. RAD51 recombinase inhibitor overcomes imatinib-resistance in chronic myeloid leukaemia. PMID: 23341130
16. activated Akt1 in Brca1-deficient cells impairs Chk1 nuclear localization and subsequently disrupts interaction of Chk1 and Rad51 leading to homologous recombination defects. PMID: 22665067
17. The control of protein levels of Rad51 in mouse embryonic stem cells and mouse embryo fibroblasts, was investigated. PMID: 22705496
18. The RAD51 was highly variable from cell to cell, whereas foci of the crossover marker MLH1 showed little variability. PMID: 22388890
19. we postulate that BCR-ABL1 kinase-mediated RAD51(pY315) promotes unfaithful homeologous recombination repair in leukemia cells PMID: 21653319
20. BRCA1 and BRCA2 heterozygosity in embryonic stem cells reduces radiation-induced Rad51 focus formation but is not associated with radiosensitivity. PMID: 20979543
21. Results collectively support a critical role for both Rad51 and Bax in oocyte death during aging and following DXR treatment. PMID: 20169201
22. An important function of XRCC2 is to enhance the activity of RAD51, so that the loss of XRCC2 results in a severe delay in the early response of RAD51 to DNA damage. PMID: 20189471
23. role of RAD51-induced hydrolysis in homology-directed DNA repair PMID: 11923292
24. Rad51 levels modify both homologous and illegitimate recombination, but these phenomena are independent of p53 status. PMID: 12749858
25. first direct evidence of involvement of RAD51 in tumor repression PMID: 14576820
26. RECQL5 displaces Rad51 from single-stranded DNA (ssDNA) in a reaction that requires ATP hydrolysis PMID: 18003859
27. Loss of Rad51 function as a critical underlying factor in the homologous recombination defect in the Brca2-depleted cells. PMID: 18992372
28. The sister chromatid exchange events stimulated by Tim reduction were largely mediated via a Brca2/Rad51-dependent mechanism and were additively increased by deletion of the Blm helicase. PMID: 19112184

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KEGG: mmu:19361

STRING: 10090.ENSMUSP00000028795

UniGene: Mm.330492