RPN4 Antibody

1. Rpn4 induces TMC1 transcription in response to misfolded proteins. However, this response is counteracted by rapid proteasome-dependent degradation of Tmc1, which serves to normalize Tmc1 protein levels after induction PMID: 27226598
2. Rpn4-responsive elements in genes related to proteasome functions PMID: 25747386
3. under the methyl methanesulfonate stress Rpn4 promotes the regulation of several genes involved in DNA repair, antioxidant response and glucose metabolism. PMID: 25842837
4. the ubiquitin-independent degradation of Rpn4 requires the 19S regulatory particle. PMID: 22349505
5. evidence for the role of proteasomal degradation of Rpn4 in nonhomologous end-joining PMID: 20376190
6. Intracellular proteasome activity is correlated with the transactivation potency of Rpn4. PMID: 19914394
7. Rpn4 thus represents an important stress-responsive mediator whose degradation as well as availability are critical for cell survival under stressed conditions. PMID: 19933873
8. analysis of Rpn4 ubiquitination site and ubiquitin-dependent degradation signal PMID: 16492666
9. expression regulated by HSF in response to heat shock and MMS treatments PMID: 16556235
10. These results indicate that ubiquitin-mediated degradation of Rpn4 is controlled by a phosphorylation-dependent ubiquitylation signal. PMID: 17532487
11. These data suggest that Mub1 and Ubr2 cooperate to transfer ubiquitin to Rpn4 from Rad6 and that Mub1 may switch from a partner to a substrate of the Ubr2/Rad6 ubiquitin ligase. PMID: 18070918
12. This activation of FLR1 transcription is fully dependent on Yap1p and is reduced (by 50%) in the absence of Rpn4p, Yrr1p or Pdr3p. PMID: 18086556
13. Rpn4p may act as an activator or repressor for the genes of the ubiquitin-proteasome system. PMID: 18702311
14. Rpn4p devoid of its C-terminal region containing the zinc finger DNA-binding domains and its N-terminus, which shares no homology with transactivation domains of known transcription factors, was completely unable to activate transcription. PMID: 18702312
15. The Rpn4p transactivation domains were mapped by deletion analysis. PMID: 18804109
16. the physiological function of Rpn4-induced proteasome expression PMID: 18832351
17. The requirement for Rpn4p reflects severe impairment of the proteasome by unfolded protein response-membrane stress. PMID: 19073890

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KEGG: sce:YDL020C

STRING: 4932.YDL020C