rpr Antibody

1. The rapid induction of apoptosis requires the P53 and is mediated by a stress-responsive regulatory region upstream of reaper. The rapid induction of apoptosis is responsible for preventing the expression of viral genes and blocking the infection. PMID: 23408884
2. dBruce physically interacts with Reaper, dependent upon Reaper's IAP-binding (IBM) and GH3 motifs. PMID: 21886178
3. Eliminating Foxo, together with inhibition of reaper family proapoptotic genes, promotes long-term survival of neuroblasts and sustains neurogenesis in the adult mushroom body, the center for learning and memory. PMID: 20346676
4. Rpr mediates programmed cell death during drosophila development PMID: 11853767
5. the central nervous systems of rpr null flies were very enlarged. This was due to the inappropriate survival of both larval neurons and neuroblasts. PMID: 11880355
6. Reaper eliminates IAP proteins through stimulated IAP degradation and generalized translational inhibition. PMID: 12021770
7. regulation by inhibitor of apoptosis protein-mediated ubiquination PMID: 12446669
8. Bifunctional killing activity is encoded by conserved reaper proteins. PMID: 15002042
9. Internal ribosome entry site drives cap-independent translation of rpr mRNA in Drosophila embryos. PMID: 15496524
10. Reaper is located downstream of LKB1 and is invloved in LKB1 sependent apoptosis. PMID: 16273080
11. Reaper is the first known cellular ribosomal binding factor with the potential to allow selective translation of mRNAs initiating at alternative start codons or from certain IRES elements PMID: 16429152
12. Data provide a function for the GH3 domain in conferring protein-lipid interactions, demonstrate that both Reaper binding and mitochondrial localization are required for accelerated IAP degradation. PMID: 17998202
13. Data show that all factors studied have very specific temporal and spatial effects on rpr transcription. PMID: 19602391

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KEGG: dme:Dmel_CG4319

STRING: 7227.FBpp0074886

UniGene: Dm.2529