sel-10 Antibody

Code CSB-PA835911XA01CXY
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Product Details

Full Product Name
Rabbit anti-Caenorhabditis elegans sel-10 Polyclonal antibody
Uniprot No.
Target Names
sel-10
Alternative Names
sel-10 antibody; egl-41 antibody; F55B12.3 antibody; F-box/WD repeat-containing protein sel-10 antibody; Egg laying defective protein 41 antibody; Suppressor/enhancer of lin-12 protein 10 antibody
Raised in
Rabbit
Species Reactivity
Caenorhabditis elegans
Immunogen
Recombinant Caenorhabditis elegans sel-10 protein
Immunogen Species
Caenorhabditis elegans
Conjugate
Non-conjugated
Clonality
Polyclonal
Isotype
IgG
Purification Method
Antigen Affinity Purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Tested Applications
ELISA, WB (ensure identification of antigen)
Protocols
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Value-added Deliverables
① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);
Quality Guarantee
① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;
Lead Time
Made-to-order (14-16 weeks)

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Target Background

Function
Probable substrate recognition component of SCF (SKP1-CUL-F-box protein) E3 ubiquitin-protein ligase complex, which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Regulates synapse elimination in early development in the motor neuron HSNL. Cell autonomous negative regulator of lin-12/Notch-mediated signaling, with respect to lin-12 activity in cell fate decisions and tumorigenesis. May target the intracellular domains of lin-12/Notch proteins for ubiquitin-dependent degradation. Involved in sex determination by promoting female development. Potential regulator of presenilin. May have a role in egg laying. Regulates zyg-1 levels (possibly redundantly with lin-23) to control centrosome duplication during mitosis. Negatively regulates lin-45 activity and protein stability, probably by targeting it for ubiquitination and proteasomal degradation.
Gene References into Functions
  1. Data show that a second F-box protein, SEL-10, also contributes to ZYG-1 regulation. Co-depletion of LIN-23 and SEL-10 suggests these proteins function cooperatively. PMID: 22623721
  2. Combined analysis of the SAO-1-SEL-10 protein interaction and comparisons of sao-1 and sel-10 genetic interactions suggest a possible role for SAO-1 as an accessory protein that participates with SEL-10 in downregulation of Notch signaling. PMID: 22209900
Subcellular Location
Cell projection, axon. Cytoplasm.
Tissue Specificity
Expressed in tail and head neurons.
Database Links

KEGG: cel:CELE_F55B12.3

STRING: 6239.F55B12.3a

UniGene: Cel.2743

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