Sply Antibody

Datasheet

Code	CSB-PA895577XA01DLU
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Product Details

Full Product Name

Rabbit anti-Drosophila melanogaster (Fruit fly) Sply Polyclonal antibody

Uniprot No.

Q9V7Y2

Target Names

Sply

Alternative Names

Sply antibody; Spl antibody; CG8946 antibody; Sphingosine-1-phosphate lyase antibody; S1PL antibody; SP-lyase antibody; SPL antibody; EC 4.1.2.27 antibody; Sphingosine-1-phosphate aldolase antibody

Raised in

Rabbit

Species Reactivity

Drosophila melanogaster (Fruit fly)

Immunogen

Recombinant Drosophila melanogaster (Fruit fly) Sply protein

Immunogen Species

Drosophila melanogaster (Fruit fly)

Conjugate

Non-conjugated

Clonality

Polyclonal

Isotype

IgG

Purification Method

Antigen Affinity Purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form

Liquid

Tested Applications

ELISA, WB (ensure identification of antigen)

Protocols

ELISA Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Value-added Deliverables

① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);

Quality Guarantee

① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;

Lead Time

Made-to-order (14-16 weeks)

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Target Background

Function

Cleaves phosphorylated sphingoid bases (PSBs), such as sphingosine-1-phosphate, into fatty aldehydes and phosphoethanolamine. Sphingolipid catabolism is required for normal development including viability, reproduction and muscle development.

Gene References into Functions

In Drosophila, Sply mutants, which lack SGPL1, displayed a phenotype reminiscent of nephrotic syndrome in nephrocytes. PMID: 28165339
cloning of the sphingosine-1-phosphate lyase gene (Sply) and its importance for adult muscle development and integrity, reproduction and larval viability PMID: 12702658
There are defects in reproductive structures and function that are associated with enhanced apoptosis in Drosophila Sply05091 mutants that lack functional S1P lyase and thereby accumulate sphingolipid long chain base metabolites. PMID: 17706961

Subcellular Location

Endoplasmic reticulum membrane; Single-pass type III membrane protein.

Protein Families

Group II decarboxylase family, Sphingosine-1-phosphate lyase subfamily

Tissue Specificity

Localized to the developing gut primordium during embryogenesis.

Database Links

KEGG: dme:Dmel_CG8946

STRING: 7227.FBpp0086158

UniGene: Dm.3390

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Service

Phage Display Service

Antibody Service

Protein Service

Gene Synthesis Service

Oligo Synthesis Service

Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

Call us

301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

[email protected]

Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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Sply Antibody

Product Details

Related Products

Customer Reviews and Q&A

Target Background