Shark Antibody

Datasheet

Code	CSB-PA636546XA01DLU
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Product Details

Full Product Name

Rabbit anti-Drosophila melanogaster (Fruit fly) shark Polyclonal antibody

Uniprot No.

Q24145

Target Names

shark

Alternative Names

Shark antibody; Tk7 antibody; CG18247Tyrosine-protein kinase Shark antibody; EC 2.7.10.2 antibody

Raised in

Rabbit

Species Reactivity

Drosophila melanogaster (Fruit fly)

Immunogen

Recombinant Drosophila melanogaster (Fruit fly) Shark protein

Immunogen Species

Drosophila melanogaster (Fruit fly)

Conjugate

Non-conjugated

Clonality

Polyclonal

Isotype

IgG

Purification Method

Antigen Affinity Purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form

Liquid

Tested Applications

ELISA, WB (ensure identification of antigen)

Protocols

ELISA Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Value-added Deliverables

① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);

Quality Guarantee

① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;

Lead Time

Made-to-order (14-16 weeks)

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Target Background

Function

Following axon injury, required for recruitment of drpr and glial cells to severed axons and for glial clearance of severed axons from the central nervous system. Together with Src42a and drpr, promotes the migration of macrophages to sites of wounding as part of a signaling cascade where Scr42a detects production of hydrogen peroxide at wound sites which triggers phosphorylation of drpr and subsequent recruitment and activation of shark. May be involved in signal transduction on the apical surface of ectodermal epithelial cells, regulating their polarity during invagination. Crumbs (crb) may be the intracellular signal.

Gene References into Functions

Required in follicle cells for cell migration and chorion deposition. PMID: 14602681

Subcellular Location

Cytoplasm. Note=Apical expression in cephalic furrow and tracheal cells. Limited to luminal surface and absent from the basal surface.

Protein Families

Protein kinase superfamily, Tyr protein kinase family

Tissue Specificity

Gastrulation embryos show expression in ectodermal cells along the cephalic furrow and ventral midline. Proctodeum, stomodeum and their derived structures (foregut, atrium, pharynx, esophagus and hindgut) continue to show expression from stage 8-9 to late

Database Links

KEGG: dme:Dmel_CG18247

STRING: 7227.FBpp0086382

UniGene: Dm.6764

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Email: [email protected]
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Service

Phage Display Service

Antibody Service

Protein Service

Gene Synthesis Service

Oligo Synthesis Service

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Call us

301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

[email protected]

Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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Shark Antibody

Product Details

Related Products

Customer Reviews and Q&A

Target Background