Product Details

Full Product Name

Rabbit anti-Arabidopsis thaliana (Mouse-ear cress) SNI1 Polyclonal antibody

Uniprot No.

Q9SWA6

Target Names

SNI1

Alternative Names

SNI1 antibody; NSE5 antibody; At4g18470 antibody; F28J12.3 antibody; Negative regulator of systemic acquired resistance SNI1 antibody; Non-structural maintenance of chromosome element 5 antibody; Non-SMC element 5 antibody; Protein SUPPRESSOR OF NPR1 antibody; INDUCIBLE 1 antibody; Suppressor of npr1-1 antibody

Raised in

Rabbit

Species Reactivity

Arabidopsis thaliana

Immunogen

Recombinant Arabidopsis thaliana SNI1 protein

Immunogen Species

Arabidopsis thaliana (Mouse-ear cress)

Conjugate

Non-conjugated

Clonality

Polyclonal

Isotype

IgG

Purification Method

Antigen Affinity Purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form

Liquid

Tested Applications

ELISA, WB (ensure identification of antigen)

Protocols

ELISA Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Value-added Deliverables

① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);

Quality Guarantee

① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;

Lead Time

Made-to-order (14-16 weeks)

Target Background

Function

Component of the SMC5-SMC6 complex, a complex involved in repair of DNA double-strand breaks by homologous recombination. Transcription repressor that prevents expression of pathogenesis-related genes (PR) via histone modifications and binding negative cis-acting elements at their promoters. Negative regulator of hypersensitive response (HR) and systemic acquired resistance (SAR) required to dampen the basal expression of pathogenesis related (PR) genes. Functions synergistically with NTL9/CBNAC as negative regulator of pathogen-induced PR1 expression and basal resistance to a virulent strain of P.syringae. Binds to the PR1 gene promoter to suppress defense response in the absence of pathogen challenge and is removed in response to induction. Regulates negatively both gene expression and DNA recombination during pathogen infection, thus being involved in short-term defense response and a long-term survival strategy. Prevents effective immune responses that involve activation of DNA damage responses, probably by negatively regulating the DNA damage sensors RAD17 and ATR. Negative regulator of defenses against the beet cyst nematode H.schachtii.

Gene References into Functions

Transfected Arabidopsis negative regulator of systemic acquired resistance (SNI1) protein inhibited DNA damage repair in human osteosarcoma U2OS cancer cells. PMID: 27648563
SNI1 (suppressor of npr1-1, inducible 1) and ASAP1 (Arabidopsis SNI1 Associated Protein 1) are the two missing subunits of the SMC5/6 complex required for controlling DNA damage. [SNI1] PMID: 24207055
CBNAC and SNI1 are hypothesized to work together as repressor proteins in the cooperative suppression of plant basal defense. PMID: 22826500
the configuration of two TGA binding sites within the PR-1 promoter determines whether NPR1 can induce and whether SNI1 can repress the promoter PMID: 21139438
analyzed the importance of the TGA-binding sites LS5 and LS7 and the WKRY box LS4 for regulation by NPR1 and SNI1 PMID: 20935179
Results suggest that due to the structural similarity of SNI1 to Armadillo repeat proteins, SNI1 may form a scaffold for interaction with proteins that modulate transcription. PMID: 16766691
RAD51D and SNI1 have dual roles in pathogenesis-related gene transcription and DNA recombination PMID: 17360504

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Subcellular Location

Nucleus.

Tissue Specificity

Expressed at low levels in the veins.

Database Links

KEGG: ath:AT4G18470

STRING: 3702.AT4G18470.1

UniGene: At.11569

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SNI1 Antibody

Product Details

Customer Reviews and Q&A

Target Background