SWR1 Antibody

1. Functional characterization and architecture of recombinant yeast SWR1 histone exchange complex has been reported. PMID: 28499038
2. Incorporation of histone H2A.Z (Htz1) variant by SWR-C (Swr1) remodeling enzyme may stimulate Exo1 activity, as well as enhance the fidelity of replication by Pol delta, the repair of mismatches generated by Pol delta, or both. PMID: 25463393
3. the cooperative heterochromatin regulation of Asf1 and SWR1 PMID: 24578349
4. The Swr1-Z domain can deliver the H2A.Z-H2B dimer to the DNA-(H3-H4)2 tetrasome to form the nucleosome by a histone chaperone mechanism. PMID: 24507717
5. These results suggest that the combination of H2A-containing nucleosome and free H2A.Z-H2B dimer acting as both effector and substrate for SWR1 governs the specificity and outcome of the replacement reaction. PMID: 21111233
6. Results support a model where SWR1-C resides at the heterochromatin boundary to maintain and amplify antisilencing activity of histone H4 acetylation through incorporating H2A.Z into chromatin. PMID: 20308321
7. Swr1p has a role in depositing histone variant H2A.Z into euchromatin PMID: 15045029
8. Yaf9 may function in NuA4 and SWR1 complexes to help antagonize silencing near telomeres PMID: 15485911
9. NuA4 and Swr1 complexes act throughout the genome while only a specific subset of the genome shows alterations in transcription. PMID: 16880522
10. Ino80 and Swr1 function antagonistically at chromatin surrounding a double-strand break; they regulate the incorporation of different histone H2A variants that can either promote or block cell cycle checkpoint adaptation. PMID: 16951256
11. These two related chromatin remodelers, INO80 and SWR1 have distinct roles in double-strand break repair and checkpoint activation. PMID: 17762868

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KEGG: sce:YDR334W

STRING: 4932.YDR334W