Tk Antibody

Code CSB-PA892843XA01DLU
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Product Details

Full Product Name
Rabbit anti-Drosophila melanogaster (Fruit fly) Tk Polyclonal antibody
Uniprot No.
Target Names
Alternative Names
Tk antibody; CG14734 antibody; Tachykinins antibody; dTk) [Cleaved into: Tachykinin-related peptide 1 antibody; TK-1 antibody; dTK-1 antibody; APTSSFIGMR-amide); Tachykinin-associated peptide 1 antibody; TAP1 antibody; DEEHDTSEGNWLGSGPDPLDYADEEADSSYAEN-amide); Tachykinin-related peptide 2 antibody; TK-2 antibody; dTK-2 antibody; APLAFVGLR-amide); Tachykinin-associated peptide 2 antibody; TAP2 antibody; FIPINNRLSDVLQSLEEERLRDSLLQDFFDRVAGRDGSAV-amide); Tachykinin-related peptide 3 antibody; TK-3 antibody; dTK-3 antibody; APTGFTGMR-amide); Tachykinin-associated peptide 3 antibody; TAP3 antibody; Brain peptide PALLAGDDDAEADEATELQQ); Tachykinin-related peptide 4 antibody; TK-4 antibody; dTK-4 antibody; APVNSFVGMR-amide); Tachykinin-associated peptide 4 antibody; TAP4 antibody; Brain peptide DVSHQHY); Tachykinin-associated peptide 5 antibody; TAP5 antibody; AALSDSYDLRGKQQRFADFNSKFVAVR-amide); Tachykinin-associated peptide 6 antibody; TAP6 antibody; Brain peptide SDLEGNGVGIGDDHEQALVHPWLYLWGE); Tachykinin-related peptide 5 antibody; TK-5 antibody; dTK-5 antibody; APNGFLGMR-amide)] antibody
Raised in
Rabbit
Species Reactivity
Drosophila melanogaster (Fruit fly)
Immunogen
Recombinant Drosophila melanogaster (Fruit fly) Tk protein
Immunogen Species
Drosophila melanogaster (Fruit fly)
Conjugate
Non-conjugated
Clonality
Polyclonal
Isotype
IgG
Purification Method
Antigen Affinity Purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Tested Applications
ELISA, WB (ensure identification of antigen)
Protocols
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Value-added Deliverables
① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);
Quality Guarantee
① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;
Lead Time
Made-to-order (14-16 weeks)

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Target Background

Function
Tachykinins are active peptides which excite neurons, evoke behavioral responses, are potent vasodilators and secretagogues, and contract (directly or indirectly) many smooth muscles. Stimulates gut muscle contractions. Required for the response to the male sex pheromone CH503 which is transferred from males to females during mating and inhibits courtship behavior by other males. The Gr68a gustatory receptor is required for detection of the pheromone and Gr68a-expressing neurons in the male foreleg relay signals to the suboesophageal zone (SEZ) which leads to courtship suppression through release of tachykinin from a cluster of 8-10 neurons in the SEZ.
Gene References into Functions
  1. These results highlight a conserved role for Tachykinin signaling in regulating nociception. PMID: 26575288
  2. Study identified a small group of sexually dimorphic, FruM+ neurons that promote aggressiveness in Drosophila males but have no influence on male-female courtship behavior. These neurons enhance aggression, at least in part, through the release of a neuropeptide, Drosophila tachykinin. PMID: 24439378
  3. The control of DILP5 signaling in the renal tubules by Drosophila tachykinin peptide (DTK) and its receptor DTKR during desiccative, nutritional and oxidative stress, was investigated. PMID: 21572965
  4. The distribution of the Dtk transcript and peptides was analyzed by in situ hybridization and immunocytochemistry during postembryonic development of the central nervous system (CNS) of Drosophila. PMID: 12898611
Subcellular Location
Secreted.
Protein Families
Tachykinin family
Tissue Specificity
Strong expression is seen in a group of 14 cells plus one isolated cell in the midgut of stage 17 embryos. Also expressed in a pair of medially located unidentified cells, just posterior to the brain, and in two lateral groups of cells that may be associa
Database Links

KEGG: dme:Dmel_CG14734

STRING: 7227.FBpp0081962

UniGene: Dm.3420

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