wrn-1 Antibody

Datasheet

Code	CSB-PA623291XA01CXY
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Target Background

Product Details

Full Product Name

Rabbit anti-Caenorhabditis elegans wrn-1 Polyclonal antibody

Uniprot No.

Q19546

Target Names

wrn-1

Alternative Names

wrn-1 antibody; F18C5.2 antibody; Probable Werner syndrome ATP-dependent helicase homolog 1 antibody; EC 3.6.4.12 antibody

Raised in

Rabbit

Species Reactivity

Caenorhabditis elegans

Immunogen

Recombinant Caenorhabditis elegans wrn-1 protein

Immunogen Species

Caenorhabditis elegans

Conjugate

Non-conjugated

Clonality

Polyclonal

Isotype

IgG

Purification Method

Antigen Affinity Purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form

Liquid

Tested Applications

ELISA, WB (ensure identification of antigen)

Protocols

ELISA Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Value-added Deliverables

① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);

Quality Guarantee

① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;

Lead Time

Made-to-order (14-16 weeks)

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Target Background

Function

Essential for the formation of DNA replication focal centers; stably associates with foci elements generating binding sites for RP-A. Exhibits a magnesium-dependent ATP-dependent DNA-helicase activity. May be involved in the control of genomic stability.

Gene References into Functions

WRN-1 plays a conserved role in the resection of DSB ends and mediates checkpoint signaling, thereby influencing levels of RPA and RAD-51 PMID: 28640365
WRN-1 functions downstream of RPA-1 and upstream of CHK-1 in the DSB checkpoint pathway and is also required for the repair of DSB. PMID: 26691982
analysis of physical and functional interactions of Caenorhabditis elegans WRN-1 helicase with RPA-1 PMID: 22257160
WRN-1 functions together with RPA-1 upstream of ATM and ATR to trigger cell cycle arrest in response to double-strand DNA breaks. PMID: 20062519
WRN-1 acts as a checkpoint protein for DNA damage and replication blockage. PMID: 15115755
This protein is able to unwind DNA structures may improve the access for DNA repair and replication proteins that are important for preventing the accumulation of abnormal structures. PMID: 18558712

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Subcellular Location

Nucleus.

Protein Families

Helicase family, RecQ subfamily

Database Links

KEGG: cel:CELE_F18C5.2

STRING: 6239.F18C5.2

UniGene: Cel.7245

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Service

Phage Display Service

Antibody Service

Protein Service

Gene Synthesis Service

Oligo Synthesis Service

Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

[email protected]

Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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wrn-1 Antibody

Product Details

Related Products

Customer Reviews and Q&A

Target Background