emb Antibody

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Code	CSB-PA874697XA01DLU
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Target Background

Product Details

Full Product Name

Rabbit anti-Drosophila melanogaster (Fruit fly) emb Polyclonal antibody

Uniprot No.

Q9TVM2

Target Names

emb

Alternative Names

emb antibody; Crm1 antibody; CG13387 antibody; Exportin-1 antibody; Chromosome region maintenance 1 protein antibody; Protein embargoed antibody

Raised in

Rabbit

Species Reactivity

Drosophila melanogaster (Fruit fly)

Immunogen

Recombinant Drosophila melanogaster (Fruit fly) emb protein

Immunogen Species

Drosophila melanogaster (Fruit fly)

Conjugate

Non-conjugated

Clonality

Polyclonal

Isotype

IgG

Purification Method

Antigen Affinity Purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form

Liquid

Tested Applications

ELISA, WB (ensure identification of antigen)

Protocols

ELISA Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Value-added Deliverables

① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);

Quality Guarantee

① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;

Lead Time

Made-to-order (14-16 weeks)

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Target Background

Function

Receptor for the leucine-rich nuclear export signal (NES). Binds cooperatively to the NES on its target protein and to the small GTPase Ran in its active GTP-bound form. Involved in the export of dl, RpS2 and the pre-40S ribosome from the nucleus to the cytoplasm. Plays an important role in nuclear pore assembly by mediating nucleoporin condensation and biogenesis of annulate lamellae. Required for the function or maintenance of certain tissues such as brain and gut.

Gene References into Functions

two newly identified factors that restrict diverse viruses, dXPO1 and dRUVBL1 contributed to antiviral defense at the organismal level in adult flies PMID: 24550726
HPO promotes the translocation of SD to the cytoplasm in a CRM1-dependent manner PMID: 23271049
Exportin-1 is a nuclear export receptor for expanded polyQ containing proteins. PMID: 21300695
Nuclear localization of the ecdysteroid receptor (EcR) is increased in HeLa cells if exportin-1 (CRM1) is knocked down by siRNA against exportin. PMID: 21125558
Data show that downregulation of YAN involves CRM1-mediated nuclear export, and that MAE is involved in MAPK phosphorylationof YAN. PMID: 12538513
A major function of DNup88 is to anchor DNup214 and CRM1 on the nuclear envelope and thereby attenuate NES-mediated nuclear export. PMID: 14638854
Phosphorylation of Yan favors Crm1 in this competition and counteracts inhibition of nuclear export by Mae PMID: 16027171
two functional nuclear export signals are in the Sima basic helix-loop-helix (bHLH) domain and promote CRM1-dependent nuclear export PMID: 18332128

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Subcellular Location

Nucleus. Nucleus membrane; Peripheral membrane protein; Nucleoplasmic side.

Protein Families

Exportin family

Tissue Specificity

High expression observed in the developing embryonic brain, hind gut and posterior spiracles shortly before dorsal closure; and in the ventral nerve cord, midgut and somatic musculature shortly after dorsal closure. Expression increases when the tissue is

Database Links

KEGG: dme:Dmel_CG13387

STRING: 7227.FBpp0079278

UniGene: Dm.3346

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emb Antibody

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