Code | CSB-E13157h |
Size | 96T,5×96T,10×96T |
Price | Request a Quote or Start an on-line Chat |
Trial Size |
24T ELISA Kit Trial Size (Only USD$150/ kit) * Sample kit cost can be deducted as a $30 credit for each 96-assay kit of the same analyte and brand you subsequently purchase in six months till depleted. Apply now |
CUSABIO's human MMP14 ELISA kit is an in vitro enzyme-linked immunosorbent assay for quantitatively measuring human MMP14 in serum, plasma, or tissue homogenates. This assay uses the sandwich enzyme immunoassay technique in combination with the enzyme-substrate chromogenic reaction to quantify the analyte in the sample. The color develops positively to the amount of MMP14 in samples. The color intensity is measured at 450 nm via a microplate reader.
MMP14 is a potent pericellular collagenase that can cleave extracellular matrix (ECM) macromolecules especially type I collagen. It is thus involved in cancer cell invasion and embryonic development. MMP14 plays a prominent role in the angiogenesis by degradation of collagen types I, II, and III. It promotes cellular invasion in cancerogenic processes, metastasis, angiogenesis, wound healing, atherosclerosis, and rheumatoid arthritis.MMP14 enhances the local invasion of the tumor and the formation of metastases by activating pro-MMP-2. Increased expression of MMP14 seemed to be related to a high degree of malignancy, aggressiveness, and survival prognosis.
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