Code | CSB-MA294403 |
Size | US$166 |
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Application | Recommended Dilution |
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IHC | 1:20-1:200 |
The ENG monoclonal antibody is produced using the synthesized peptide derived from human CD105 protein as an immunogen. B cells are isolated from the immunized mouse and then fused with myeloma cells to create hybridoma cells that are screened to identify the cell line that produces the ENG antibody. The CD105 monoclonal antibody is affinity-purified from mouse ascites by affinity-chromatography using a specific immunogen. The purified antibody is an unconjugated IgG2b, Kappa. It can recognize human ENG protein in ELISA and IHC applications.
Endoglin (ENG), also known as CD105, is primarily expressed on endothelial cells and plays a critical role in angiogenesis. Endoglin functions as a co-receptor for TGF-β1 and TGF-β3, binding to these cytokines and enhancing their signaling activity in endothelial cells. It also interacts with other cell surface receptors, such as integrins, and extracellular matrix proteins, facilitating cell adhesion and migration. In addition, Endoglin has been shown to regulate vascular permeability, participate in vascular inflammation, and modulate cellular responses to oxidative stress.
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