BZLF2 Antibody, FITC conjugated

Datasheet

Code	CSB-PA365876LC01EFA
Size	US$166
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Product Details
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Target Background

Product Details

Full Product Name

Rabbit anti-Epstein-Barr virus (strain B95-8) (HHV-4) (Human herpesvirus 4) BZLF2 Polyclonal antibody

Uniprot No.

P03205

Target Names

BZLF2

Alternative Names

BZLF2Glycoprotein 42 antibody; gp42) [Cleaved into: Soluble gp42] antibody

Raised in

Rabbit

Species Reactivity

Epstein-Barr virus

Immunogen

Recombinant Epstein-Barr virus Glycoprotein 42 protein (34-223AA)

Immunogen Species

Epstein-Barr virus (strain B95-8) (HHV-4) (Human herpesvirus 4)

Conjugate

FITC

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form

Liquid

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function

Plays a role in virion attachment to host B-lymphocytes, through binding to leukocyte antigen (HLA) class II and subsequently participates in fusion of the virion with host membranes. May act as a tropism switch that directs fusion with B-lymphocytes and inhibits fusion with epithelial cells. Additionally, hampers T-cell recognition via HLA class II molecules through steric hindrance of T-cell receptor-class II-peptide interaction.; Soluble gp42 inhibits HLA class II-restricted antigen presentation to T-cells through binding to immature and mature HLA class II complexes.

Gene References into Functions

gp42 mutants bound to gH/gL and HLA class II, but not wild-type gp42 or cleavage mutant of gp42; using purified gp42, gH/gL, and HLA, found these proteins associate 1:1:1 suggesting gp42 dimerization or multimerization does not occur or is transient PMID: 21550622
reveal distinct functional requirements for gH/gL and gp42 complexes in Epstein-Barr virus-mediated membrane fusion PMID: 16973550
This screening demonstrates that LF2 specifically interacts with the central inhibitory association domain of IRF7, and this interaction leads to inhibition of the dimerization of IRF7, which suppresses IFN-alpha production and IFN-mediated immunity. PMID: 18987133
Enhanced secretion of gp42 promoted fusion with B lymphocytes, and mutation of the site of gp42 cleavage inhibited membrane fusion activity. PMID: 19369343

Subcellular Location

Virion membrane. Host membrane; Single-pass membrane protein.

Protein Families

Epstein barr virus gp42 family

Database Links

KEGG: vg:3783745

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Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

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7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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