LAMC3 Antibody

Code CSB-PA914944
Size US$297
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  • Western blot analysis of extracts from K562 cells and 3T3 cells, using LAMC3 antiobdy.
  • Immunohistochemistry analysis of paraffin-embedded human brain tissue using LAMC3 antibody.
  • Immunofluorescence analysis of LOVO cells, using LAMC3 antibody.
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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) LAMC3 Polyclonal antibody
Uniprot No.
Target Names
Alternative Names
LAMA 1 antibody; LAMA antibody; LAMA1 antibody; LAMB1 antibody; Lamc3 antibody; LAMC3_HUMAN antibody; Laminin A chain antibody; Laminin alpha 1 antibody; Laminin alpha 1 chain antibody; Laminin B1 chain antibody; Laminin subunit beta 1 antibody; Laminin subunit gamma-3 antibody; Laminin-12 subunit gamma antibody; Laminin-14 subunit gamma antibody; Laminin-15 subunit gamma antibody
Raised in
Rabbit
Species Reactivity
Human,Mouse
Immunogen
Synthesized peptide derived from internal of Human LAMC3.
Immunogen Species
Homo sapiens (Human)
Clonality
Polyclonal
Purification Method
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration
It differs from different batches. Please contact us to confirm it.
Form
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Tested Applications
ELISA,WB,IHC,IF
Recommended Dilution
Application Recommended Dilution
WB 1:500-1:3000
IHC 1:50-1:100
IF 1:100-1:500
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components.
Gene References into Functions
  1. LAMC3 gene variation is associated with oral cavity and pharyngeal cancer. PMID: 27749845
  2. We found statistically significant association with AAO for three genes (WRN, NTN4 and LAMC3) with common associated variants. PMID: 26394601
  3. These data suggest that beta2 and gamma3-containing laminins play an important dose-dependent role in development of the cortical pial basement membrane PMID: 22961762
  4. Recessive LAMC3 mutations cause malformations of occipital cortical development. PMID: 21572413
  5. Laminin isoforms containing the gamma3 chain are unable to bind to integrins due to the absence of the glutamic acid residue conserved in the C-terminal regions of the gamma1 and gamma2 chains PMID: 18697739

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Involvement in disease
Cortical malformations occipital (OCCM)
Subcellular Location
Secreted, extracellular space, extracellular matrix, basement membrane.
Tissue Specificity
Broadly expressed in: skin, heart, lung, and the reproductive tracts.
Database Links

HGNC: 6494

OMIM: 604349

KEGG: hsa:10319

STRING: 9606.ENSP00000354360

UniGene: Hs.201805

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