PACS2 Antibody, Biotin conjugated

Code CSB-PA017372LD01HU
Size US$166
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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) PACS2 Polyclonal antibody
Uniprot No.
Target Names
PACS2
Alternative Names
6720425G15Rik antibody; AW208651 antibody; AW489976 antibody; E230011J22 antibody; FLJ25488 antibody; KIAA0602 antibody; mKIAA0602 antibody; PACS 2 antibody; PACS-2 antibody; PACS1 like protein antibody; PACS1-like protein antibody; PACS1L antibody; PACS2 antibody; PACS2_HUMAN antibody; Phosphofurin acidic cluster sorting protein 1 like antibody; Phosphofurin acidic cluster sorting protein 2 antibody
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Recombinant Human Phosphofurin acidic cluster sorting protein 2 protein (268-465AA)
Immunogen Species
Homo sapiens (Human)
Conjugate
Biotin
Clonality
Polyclonal
Isotype
IgG
Purification Method
>95%, Protein G purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Tested Applications
ELISA
Protocols
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Multifunctional sorting protein that controls the endoplasmic reticulum (ER)-mitochondria communication, including the apposition of mitochondria with the ER and ER homeostasis. In addition, in response to apoptotic inducer, translocates BIB to mitochondria, which initiates a sequence of events including the formation of mitochondrial truncated BID, the release of cytochrome c, the activation of caspase-3 thereby causing cell death. May also be involved in ion channel trafficking, directing acidic cluster-containing ion channels to distinct subcellular compartments.
Gene References into Functions
  1. These findings support the causality of this recurrent de novo PACS2 heterozygous missense in Developmental and epileptic encephalopathies with facial dysmorphim and cerebellar dysgenesis. PMID: 29656858
  2. Protein adaptation and the expanding roles of the PACS1 and PACS2 proteins in tissue homeostasis and disease has been summarized. (Review) PMID: 28476937
  3. Missense Mutation in PACS2 gene is associated with Neurodevelopmental Disorders. PMID: 28867141
  4. cIAPs constitutively downregulate PACS-2 by polyubiquitination and proteasomal degradation, thereby restraining TRAIL-induced killing of liver cancer cells PMID: 24633224
  5. The sites on Nef and the PACS proteins required for their interaction, are identified. PMID: 22496420
  6. Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) protein-induced lysosomal translocation of proapoptotic effectors is mediated by phosphofurin acidic cluster sorting protein-2. PMID: 22645134
  7. subcellular localization and function of polycystin-2 are directed by phosphofurin acidic cluster sorting protein (PACS)-1 and PACS-2 PMID: 15692563
  8. PACS-2 as a novel sorting protein that links the endoplasmic reticulum (ER)-mitochondria axis to ER homeostasis PMID: 15692567
  9. PACS-2 is required for Nef action and sorting of itinerant membrane cargo in the TGN/endosomal system PMID: 18296443
  10. the phosphorylation state of the calnexin cytosolic domain and its interaction with PACS-2 sort the chaperone between domains of the ER and the plasma membrane PMID: 18417615
  11. Results identify PACS-2 as an essential TRAIL effector, and show that Akt cooperates with 14-3-3 to regulate the homeostatic and apoptotic properties of PACS-2 that mediate TRAIL action. PMID: 19481529

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Subcellular Location
Endoplasmic reticulum. Mitochondrion.
Protein Families
PACS family
Tissue Specificity
Broadly expressed, with greatest levels in skeletal muscle followed by heart, brain, pancreas and testis.
Database Links

HGNC: 23794

OMIM: 610423

KEGG: hsa:23241

STRING: 9606.ENSP00000393559

UniGene: Hs.525626

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