PDK3 Antibody

1. We have identified a p.R158H PDK3 mutation in a Korean X-linked dominant Charcot-Marie-Tooth type 6 family PMID: 26801680
2. Reduced pyruvate flux due to R158H mutant PDK3-mediated hyper-phosphorylation of the pyruvate dehydrogenase complex is the underlying pathogenic cause of peripheral neuropathy in X-linked dominant Charcot-Marie-Tooth disease. PMID: 23297365
3. Findings suggest the HIF-1/PDK3 bioenergetic pathway as a new target for therapeutic intervention in metastatic melanoma. PMID: 22865452
4. analysis of residues in L2 and residues in the C-terminal region and the lipoyl-binding pocket of PDK3 which are critical determinants for the cross-talk between L2 and PDK3, which up-regulates PDK3 activity PMID: 16849321
5. crystal structure of the asymmetric PDHK3/lipoyl domain 2 complex; data suggest that the asymmetric complex represents a physiological state in which binding of a single L2-domain activates one of the PDHK protomers while inactivating another PMID: 17532006
6. Distinct structural mechanisms for inhibition of PDK3 by AZD7545, dichloroacetate, and radicol. PMID: 17683942
7. increased PDK3 expression due to elevated HIF-1alpha in cancer cells may play critical roles in metabolic switch during cancer progression and chemoresistance in cancer therapy PMID: 18718909

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HGNC: 8811

OMIM: 300905

KEGG: hsa:5165

STRING: 9606.ENSP00000387536

UniGene: Hs.296031