TPM3 Antibody, Biotin conjugated

Code CSB-PA024106LD01HU
Size US$166
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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) TPM3 Polyclonal antibody
Uniprot No.
Target Names
Alternative Names
Alpha tropomyosin 3 antibody; Alpha tropomyosin slow skeletal antibody; CFTD antibody; Cytoskeletal tropomyosin TM30 antibody; FLJ41118 antibody; gamma TM antibody; Gamma tropomyosin antibody; Gamma-tropomyosin antibody; Heat stable cytoskeletal protein 30 kDa antibody; hscp30 antibody; hTM30nm antibody; hTM5 antibody; hTMnm antibody; MGC102590 antibody; MGC14582 antibody; MGC3261 antibody; MGC72094 antibody; NEM1 antibody; OK/SW-cl.5 antibody; OTTHUMP00000034019 antibody; OTTHUMP00000034171 antibody; OTTHUMP00000034172 antibody; TM 5 antibody; TM-5 antibody; TM3 antibody; TM30 antibody; TM30nm antibody; TM5 antibody; Tm5NM antibody; Tpm 5 antibody; TPM3 antibody; TPM3/NTRK1 FUSION GENE, INCLUDED antibody; TPM3_HUMAN antibody; Tpm5 antibody; TPMsk3 antibody; TRK antibody; TRK ONCOGENE, INCLUDED antibody; Trop 5 antibody; Tropomyosin 3 antibody; Tropomyosin 3 gamma antibody; Tropomyosin 5 antibody; Tropomyosin alpha 3 chain antibody; Tropomyosin alpha-3 chain antibody; Tropomyosin gamma antibody; Tropomyosin-3 antibody; Tropomyosin-5 antibody
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Recombinant Human Tropomyosin alpha-3 chain protein (18-224AA)
Immunogen Species
Homo sapiens (Human)
Conjugate
Biotin
Clonality
Polyclonal
Isotype
IgG
Purification Method
>95%, Protein G purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Tested Applications
ELISA
Protocols
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Binds to actin filaments in muscle and non-muscle cells. Plays a central role, in association with the troponin complex, in the calcium dependent regulation of vertebrate striated muscle contraction. Smooth muscle contraction is regulated by interaction with caldesmon. In non-muscle cells is implicated in stabilizing cytoskeleton actin filaments.
Gene References into Functions
  1. Analysis of the residual, resected tumor identified a chromoplectic TPM3-ALK rearrangement that involved many other known oncogenes and was confirmed by rtPCR. PMID: 27742657
  2. expression levels of tropomyosin 3 (TPM3) were higher in stage III ESCC tissue compared with stage I (P<0.05). The findings of the present study identified twelve proteins, which are closely associated with ESCC invasion and metastasis, apoptosis and cell signal transduction. PMID: 28138712
  3. Dominant mutations in TPM3, encoding alpha-tropomyosinslow, cause a congenital myopathy characterized by generalized muscle weakness. Here, we used a multidisciplinary approach to investigate the mechanism of muscle dysfunction in 12 TPM3-myopathy patients. PMID: 26307083
  4. This work expands the phenotypic spectrum of TPM3-related disease and provides insights into the pathophysiological mechanisms of the actin-tropomyosin complex PMID: 26418456
  5. Western blot showed phosphorylation of ALK, ERK1/2, and STAT3 in cells transfected with TPM3-ALK. Coiled-coil structure of TPM3 contributes to the transforming ability of the TPM3-ALK fusion protein, and longer TPM3 region leads to higher dimer formation. PMID: 25596129
  6. DATA show that tropomyosin 3 protein (TPM3) plays a critical role in the progression of gliomas. PMID: 24913705
  7. study reports on a three-generation family with cap myopathy caused by a novel heterozygous mutation in TPM3 PMID: 24239060
  8. TPM3-R167H mutations decreased cooperative thin filament activation in combination with reductions in the myosin cross-bridge number and force production. PMID: 22798622
  9. TPM3 is an interacting partner of granulin-epithelin precursor and may play an important role in hepatocarcinogenesis. PMID: 22792281
  10. investigation of biomarkers for early diagnosis of endometriosis: Data suggest that TPM3, stomatin-like protein 2, and tropomodulin 3 are autoantigens present in blood of women with endometriosis; immunodominant epitopes were identified. PMID: 22158085
  11. study reports clinico-pathological and electrophysiological features of 2 unrelated cases with heterozygous TPM3 mutation; cases highlight neuromuscular transmission defect in congenital myopathy with fibre type disproportion secondary to TPM3 mutations PMID: 20951040
  12. High TPM3-PDGFRB fusion protein expression is associated with chronic eosinophilic leukemia. PMID: 21072821
  13. variation in the tropomyosin isoform composition of microfilaments provides a mechanism to generate functionally distinct filament populations PMID: 21036167
  14. TPM3 mutations are involved in fiber size disproportion in congenital myotonic dystrophy PMID: 20179953
  15. the clinical, myopathological and muscle MRI findings in a German family with autosomal dominant nemaline myopathy due to a novel pathogenic TPM3 mutation PMID: 20012312
  16. Overexpression of TPM3 activates Snail mediated EMT, which will repress E-cadherin expression and that it confers migration or invasion potentials to HCC cells during hepatocarcinogenesis. PMID: 20356415
  17. Conditional TPM3-ALK and NPM-ALK transgenic mice develop reversible ALK-positive early B-cell lymphoma/leukemia. PMID: 20223922
  18. Mutations in TPM3 were identified in 6 out of 13 patients with Congenital fiber type disproportion, as well as in one case of nemaline myopathy. PMID: 19953533
  19. cloned and sequenced a novel nonmuscle tropomyosin (hTM) isoform, TC22, which is strongly associated with colonic neoplasia and carcinoma PMID: 12105844
  20. A mutation converting the stop codon to a serine and a second splicing mutation predicted to prevent inclusion of skeletal muscle exon IX were found associated with nemaline myopathy PMID: 12196661
  21. De novo missense mutation in a constitutively expressed exon of the slow alpha-tropomyosin gene TPM3 associated with an atypical, sporadic case of nemaline myopathy. PMID: 12467750
  22. tropomyosin isoforms regulate neuronal size and shape PMID: 15888546
  23. second pedigree with autosomal dominant nemaline myopathy caused by TPM3 mutation(Arg167His). PMID: 17376686
  24. Mutation of TPM3 is the most common cause of congenital fiber type disproportion reported to date. PMID: 18300303
  25. The mutation reported here is the first deletion to be identified in TPM3, and it is likely to be a founder mutation in the Turkish population. PMID: 18382475
  26. TTC9A acts as a chaperone protein to facilitate the function of tropomyosins (including Tm5NM-1) in stabilizing microfilament and it may play a role in cancer cell invasion and metastasis PMID: 18699990
  27. We report a TPM3 mutation in one of the original cases of cap disease. PMID: 19487656

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Involvement in disease
Nemaline myopathy 1 (NEM1); Myopathy, congenital, with fiber-type disproportion (CFTD); Cap myopathy 1 (CAPM1)
Subcellular Location
Cytoplasm, cytoskeleton.
Protein Families
Tropomyosin family
Database Links

HGNC: 12012

OMIM: 164970

KEGG: hsa:7170

STRING: 9606.ENSP00000357516

UniGene: Hs.535581

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