Purity
Greater than 90% as determined by SDS-PAGE.
Research Area
More proteins and peptides
Alternative Names
GABA(A) receptor subunit beta-2
Species
Homo sapiens (Human)
Expression Region
26-244aa
Target Protein Sequence
SVNDPSNMSLVKETVDRLLKGYDIRLRPDFGGPPVAVGMNIDIASIDMVSEVNMDYTLTMYFQQAWRDKRLSYNVIPLNLTLDNRVADQLWVPDTYFLNDKKSFVHGVTVKNRMIRLHPDGTVLYGLRITTTAACMMDLRRYPLDEQNCTLEIESYGYTTDDIEFYWRGDDNAVTGVTKIELPQFSIVDYKLITKKVVFSTGSYPRLSLSFKLKRNIGY
Note: The complete sequence including tag
sequence, target protein sequence and linker sequence could be provided upon request.
Tag Info
N-terminal 6xHis-tagged
Form
Liquid or Lyophilized powder
Note: We will preferentially ship the format that
we have in stock, however, if you have any special requirement for the format, please remark your
requirement when placing the order, we will prepare according to your demand.
Buffer
If the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol.
If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, pH 8.0.
Reconstitution
We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20°C/-80°C. Our default final concentration of glycerol is 50%. Customers could use it as reference.
Storage Condition
Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw
cycles.
Shelf Life
The shelf life is related to many factors, storage state, buffer ingredients, storage temperature
and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized
form is 12 months at -20°C/-80°C.
Lead Time
3-7 business days
Notes
Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet & COA
Please contact us to get it.
Description
The region for expressing recombinant Human GABRB2 contains amino acids 26-244. The calculated molecular weight for this GABRB2 protein is 29.3 kDa. The GABRB2 protein was expressed in e.coli. The GABRB2 gene fragment has been modified by fusing the N-terminal 6xHis tag, providing convenience in detecting and purifying the recombinant GABRB2 protein during the following stages.
The human Gamma-aminobutyric acid receptor subunit beta-2 (GABRB2) is a component of the GABAA receptor, a ligand-gated ion channel that plays a crucial role in inhibitory neurotransmission within the central nervous system. GABRB2 is involved in forming functional GABAergic receptors. Activation of these receptors by the neurotransmitter gamma-aminobutyric acid (GABA) leads to an influx of chloride ions, resulting in membrane hyperpolarization and neuronal inhibition. GABRB2's presence in the GABAA receptor complex contributes to the regulation of neuronal excitability and is implicated in various neurological and psychiatric disorders, making it a target of interest in pharmacological research and drug development.