Recombinant Human Latent-transforming growth factor beta-binding protein 1 (LTBP1), partial

1. these results show peripheral blood levels of TGF beta are significantly increased in colorectal patients PMID: 29924680
2. Compared with the control, miR-340 was significantly lower in the serum of hepatocellular carcinoma patients (p<0.01). miR-340 was lower in HCC tissues than in adjacent; however, DcR3, TGF-beta1 and Smad2 were higher. PMID: 29311025
3. It is a protein that promotes renal fibrosis in diabetic nephropathy. PMID: 29549584
4. The present study demonstrated that in human osteoarthritis fibroblastlike synoviocytes, TGF-beta signals via p-Smad2 and p-Smad1/5/8. Furthermore, it was demonstrated that LTBP-1 may modulate the activity of TGF-beta in human osteoarthritis fibroblastlike synoviocytes. PMID: 29257223
5. LTBP1 anchors itself to FBN1 using two independent epitopes. PMID: 28669633
6. Expression levels of TGF-beta1 and BMP-2 appeared to be delayed in nonunion patients which could play an important role in developing an early marker of fracture union condition and facilitate improved patient's management. PMID: 28331138
7. All members of the tolloid family bind the N terminus of latent TGFb-binding protein-1, providing support for their role in TGFb signalling. PMID: 27391803
8. Eosinophils enhance Wnt-5a, TGF-beta1, fibronectin, and collagen gene expression in airway smooth muscle cells and promote proliferation of these cells in asthma. PMID: 27297409
9. LTBP-1 and LTBP-2 are involved in the keratinization of oral epithelium. PMID: 25858550
10. LTBP-1 may be a promising biomarker for distinguishing early stage hepatocellular carcinoma from the chronic hepatitis B or liver cirrhosis patients. PMID: 26884881
11. role in olive-pollen sensitization PMID: 25759826
12. Significantly higher frequency of TT genotype of transforming growth factor-Beta 1 in asthma patients was found compared to controls. PMID: 25359706
13. The aim of this study is to evaluate whether specific inhibition of c-Abl by siRNA can influence the transforming growth factor-beta1 (TGF-beta1)-induced fibrotic responses. PMID: 25527259
14. Dental pulp stem cells suppress the proliferation of lymphocytes via transforming growth factor-beta1 PMID: 25605036
15. LTBP-1 showed both an accumulation and a striking co-localization with Notch3-ECD deposits suggesting specific recruitment into aggregates in brain in CADASIL. PMID: 25190493
16. This review concludes that TGF-beta1 29T/C polymorphism does not play a role in breast cancer susceptibility in overall or ethnicity-specific manner. PMID: 25374198
17. LTBP-1 an extracellular matrix protein and key regulator of TGF-beta bioavailability is a novel HtrA1 target.Attenuation of TGF-beta signaling caused by a lack of HtrA1-mediated LTBP-1 processing as mechanism underlying CARASIL pathogenesis. PMID: 25369932
18. Combination of EGF with TGF-beta1, but not EGF or TGF-beta1 alone, caused assembly of cells to a new two-dimensional structure, being characterized by dense aggregates connected by branches of few cells. PMID: 25529149
19. There is an increasing anti-cancer protection with increased numbers of alleles associated with higher levels of TGF-beta1 and IL-4. PMID: 24164868
20. The LTBP1 C-terminus adopts a flexible "knotted rope" structure, which may facilitate cell matrix interactions. PMID: 24489852
21. these results suggested that the C allele could increase TGF-beta secretion which suppresses antitumour immune responses and may affect the Oral squamous cell carcinoma risk. PMID: 23442056
22. The expression of TGF-beta1 is increased while the Smad7 expression is diminished in dendritic cell infiltration decrease in liver gastrointestinal cancer metastasis. PMID: 23998914
23. The high incidence of intimal hyperplasia in patients with surgically repaired congenital heart disease (CHD) is correlated with TGF-beta1 expression and may contribute to the development of atherosclerotic coronary artery disease in CHD patients. PMID: 23395279
24. High transforming Growth Factor beta1 expression is associated with myelofibrosis. PMID: 23462118
25. Dysregulated expression of TWIST1, TGF-beta1 and SMAD3 mRNA observed in osteoarthritis bone is reflected in the functionality of the osteoblast when these cells are cultured ex vivo. PMID: 22820497
26. Data show that plasma TGF-beta1 was elevated in the circulation of patients with brain tumors and that significant decreases in TGF-beta1 levels were observed after the removal of benign and malignant tumors. PMID: 22632886
27. Increased generation of reactive oxygen species (ROS) and enhanced expression of NADPH oxidases were found to be associated with the TGF-beta1-induced autophagy. PMID: 22322529
28. results suggest that the CC genotype of the TGF-beta1 gene increases the risk to develop LOAD and is also associated with depressive symptoms in AD. PMID: 21924590
29. The expression of PAI-1 mRNA and TGF-beta1 mRNA was significantly higher in the cDNA samples obtained from the atopic cataracts than those obtained from the senile cataracts. PMID: 22410565
30. susceptibility genes associated with alcohol drinking PMID: 22295116
31. Elevated expression of either TGF-beta1 or TGF-beta2 in cells that represent the early stages in the development of human squamous cell carcinoma results in a more aggressive phenotype. PMID: 22414291
32. We have shown that TGF-beta1 expression in gastric tumor tissue with HER2/neu-negative status is of prognostic relevance in gastric cancer. PMID: 22015652
33. Force-induced latency-associated peptide conformational changes result in transforming growth factor (TGF)-beta1 release. Mechanical pulling opens the straitjacket structure that keeps TGF-beta1 latent. PMID: 22169532
34. genetic polymorphism is associated with both lack of microfilariae and differential microfilarial loads in the blood of persons infected with lymphatic filariasis PMID: 21843572
35. a spliced variant form of latent transforming growth factor beta binding protein 1, LTBPD41 is highly expressed in advanced atherosclerotic lesions PMID: 21161366
36. Study indicates marked differences in the expression pattern of LTBP1 mRNA and protein in early lesions compared with advanced lesions. PMID: 21071877
37. large latent TGFbeta complex (LLC), which contains latent TGFbeta-binding protein 1 (LTBP-1), is directly dependent on the pericellular assembly of fibrillin microfibrils, which interact with fibronectin during higher-order fibrillogenesis. PMID: 20699357
38. A strong negative correlation between LTBP-1 and P-Smad2 immunoreactivity was found, implying that LTBP-1 is not likely to contribute directly to the increased levels of TGF-beta activity in malignant mesothelioma. PMID: 21106222
39. extracellular HSP90beta is a negative regulator for the activation of latent TGF-beta1 modulating TGF-beta signaling in the extracellular domain. PMID: 20599762
40. TGF-beta1 gene -509C/T polymorphism was associated with severe TID. The higher value in serum concentration of TGF-beta1 was also associated with severe TID and the T T genotype/T allele. PMID: 20446778
41. TGF-beta(1) augmented Tumor necrosis factor-like weak inducer of apoptosis (TWEAK)-induced production of IL-8 and MCP-1 by retinal pigment epithelial cells. PMID: 19895311
42. Latent transforming growth factor beta-binding protein 1 interacts with fibrillin and is a microfibril-associated protein PMID: 12429738
43. The current study was carried out to understand hormonal regulation of LTBP-1 expression in normal and SV-40 virus transformed human lung fibroblasts PMID: 14626352
44. The LTBP1 protein expressed from a cDNA encoding only the TGF-beta-LAP-binding domain was incapable of supporting alphavbeta6-integrin-mediated activation. PMID: 15564041
45. The single nucleotide polymorphisms -202G/C and +20A/C on the LTBP-1L promoter may affect the clinical outcome of ovarian cancer patients, probably via up-regulating protein expression. PMID: 16825507
46. LTBP-2 specifically interacts with the amino-terminal region of fibrillin-1 and competes with LTBP-1 PMID: 17293099
47. heparan sulfate proteoglycans may play a critical role in regulating TGF-beta availability by controlling the deposition of LTBP1 into the extracellular matrix in association with fibronectin PMID: 17580303
48. MT1-MMP-mediated proteolytic processing of ECM-bound LTBP-1 is a mechanism to release latent TGF-beta from the subendothelial matrix. PMID: 18602101
49. TGFB1 as an important candidate gene for further biological studies of IgA nephropathy and as a possible target for therapy. Our data also indicate a possibility of a gender effect in the genetic background of IgA nephropathy PMID: 19258388
50. Data identify LTBP-1 as an important modulator of TGF-beta activation in glioma cells, which may contribute to the malignant phenotype. PMID: 19431147

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HGNC: 6714

OMIM: 150390

KEGG: hsa:4052

STRING: 9606.ENSP00000386043

UniGene: Hs.619315