Code | CSB-YP871382HU |
MSDS | |
Size | Pls inquire |
Source | Yeast |
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Code | CSB-EP871382HU-B |
MSDS | |
Size | Pls inquire |
Source | E.coli |
Conjugate | Avi-tag Biotinylated E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag. |
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Code | CSB-BP871382HU |
MSDS | |
Size | Pls inquire |
Source | Baculovirus |
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Code | CSB-MP871382HU |
MSDS | |
Size | Pls inquire |
Source | Mammalian cell |
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This Recombinant human Peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PPARGC1A) is a semi-custom product. There are 5 expression system options: Yeast, E. coli, In Vivo Biotinylation in E. coli, Baculovirus, and Mammalian cell. Your requirements will be given top priority in determining the protein tags. For proteins within 800 aa, risk-free custom service is guaranteed. It means you will not be charged if the protein cannot be delivered.
PPARGC1A, also known as peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC-1α), is a crucial transcriptional coactivator that regulates various biological functions, including mitochondrial biogenesis, oxidative phosphorylation, ATP production, glucose utilization, fatty acid oxidation, thermogenesis, gluconeogenesis, insulin signaling, and energy metabolism [1][2][3][4]. PPARGC1A is highly regulated and can produce multiple coactivator variants through alternative splicing [5]. It interacts with TFAM for mitochondrial DNA replication and maintenance [6].
Moreover, PPARGC1A is linked to cardiac health through its target genes, such as estrogen-related receptors (ERRs), nuclear respiratory factor-1, and PPARs, which are involved in mitochondrial gene activation, fatty acid uptake, and oxidation in the heart [7]. In skeletal muscle, PPARGC1A regulates the expression of genes related to energy metabolism and mitochondrial biogenesis, responding to external physiological stimuli [8].
References:
[1] M. Petr, P. Stastny, A. Zajac, J. Tufano, & A. Maciejewska-Skrendo, The role of peroxisome proliferator-activated receptors and their transcriptional coactivators gene variations in human trainability: a systematic review, International Journal of Molecular Sciences, vol. 19, no. 5, p. 1472, 2018. https://doi.org/10.3390/ijms19051472
[2] R. Weikard, C. Kühn, T. Goldammer, G. Freyer, & M. Schwerin, The bovine ppargc1a gene: molecular characterization and association of an snp with variation of milk fat synthesis, Physiological Genomics, vol. 21, no. 1, p. 1-13, 2005. https://doi.org/10.1152/physiolgenomics.00103.2004
[3] F. Nezhad, S. Verbrugge, M. Schönfelder, L. Becker, M. Angelis, & H. Wackerhage, Genes whose gain or loss-of-function increases endurance performance in mice: a systematic literature review, Frontiers in Physiology, vol. 10, 2019. https://doi.org/10.3389/fphys.2019.00262
[4] C. Brøns, S. Jacobsen, E. Nilsson, T. Rönn, C. Jensen, H. Storgaardet al., Deoxyribonucleic acid methylation and gene expression of ppargc1a in human muscle is influenced by high-fat overfeeding in a birth-weight-dependent manner, The Journal of Clinical Endocrinology & Metabolism, vol. 95, no. 6, p. 3048-3056, 2010. https://doi.org/10.1210/jc.2009-2413
[5] V. Martínez-Redondo, A. Pettersson, & J. Ruas, The hitchhiker’s guide to pgc-1α isoform structure and biological functions, Diabetologia, vol. 58, no. 9, p. 1969-1977, 2015. https://doi.org/10.1007/s00125-015-3671-z
[6] S. Sookoian, M. Rosselli, C. Gemma, A. Burgueño, T. Gianotti, G. Castañoet al., Epigenetic regulation of insulin resistance in nonalcoholic fatty liver disease: impact of liver methylation of the peroxisome proliferator-activated receptor γ coactivator 1α promoter, Hepatology, vol. 52, no. 6, p. 1992-2000, 2010. https://doi.org/10.1002/hep.23927
[7] T. Schillemans, V. Tragante, B. Maitusong, B. Gigante, S. Cresci, F. Laguzziet al., Associations of polymorphisms in the peroxisome proliferator-activated receptor gamma coactivator-1 alpha gene with subsequent coronary heart disease: an individual-level meta-analysis, Frontiers in Physiology, vol. 13, 2022. https://doi.org/10.3389/fphys.2022.909870
[8] A. Cesar, L. Regitano, M. Poleti, S. Andrade, P. Tizioto, P. Oliveiraet al., Differences in the skeletal muscle transcriptome profile associated with extreme values of fatty acids content, BMC Genomics, vol. 17, no. 1, 2016. https://doi.org/10.1186/s12864-016-3306-x
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