Recombinant Human Protocadherin-17 (PCDH17), partial

Code CSB-YP017530HU
MSDS
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Source Yeast
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Code CSB-EP017530HU
MSDS
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Source E.coli
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Code CSB-EP017530HU-B
MSDS
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Source E.coli
Conjugate Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
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Code CSB-BP017530HU
MSDS
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Source Baculovirus
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Code CSB-MP017530HU
MSDS
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Source Mammalian cell
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Product Details

Purity
>85% (SDS-PAGE)
Target Names
PCDH17
Uniprot No.
Alternative Names
C030033F14Rik; Gm78; PCD17_HUMAN; PCDH17; PCDH68; PCH68; Protocadherin 17; Protocadherin 68; Protocadherin-17; Protocadherin-68
Species
Homo sapiens (Human)
Protein Length
Partial
Tag Info
Tag type will be determined during the manufacturing process.
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
Form
Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
Buffer before Lyophilization
Tris/PBS-based buffer, 6% Trehalose, pH 8.0
Reconstitution
We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
Troubleshooting and FAQs
Storage Condition
Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Shelf Life
The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Lead Time
Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
Notes
Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet
Please contact us to get it.

Customer Reviews and Q&A

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Target Background

Function
Potential calcium-dependent cell-adhesion protein.
Gene References into Functions
  1. Methylation of PCDH17 could play an important role in development and progression of high-grade serous ovarian carcinoma (HGSOC)and has potential to become a target in the search for new clinical biomarkers PMID: 29991130
  2. PCDH17 methylation in serum is a potential prognostic biomarker for patients with renal cell carcinoma after surgery. PMID: 28688232
  3. PCDH17 functions as a tumor suppressor inhibiting Wnt/beta-catenin signaling and metastasis in breast cancer but is frequently methylated in primary tumors which could be a potential biomarker. PMID: 27351130
  4. Aberrant methylation of protocadherin 17 is associated with acute lymphoblastic leukemia. PMID: 27643535
  5. PCDH-17 inhibited metastasis via EGFR/MEK/ERK signaling pathway. PMID: 26386721
  6. DNA methylation in a combination of POU4F2/PCDH17 has yielded the highest sensitivity and specificity of 90.00% and 93.96% in all the 312 individuals, showing the capability of detecting bladder cancer effectively among pathologically varied sample groups. PMID: 26700620
  7. PCDH17 methylation in serum is a frequent event in early-stage prostate cancer, and it is an independent predictor of BCR after radical prostatectomy PMID: 26683656
  8. PCDH17 methylation occurred more frequently and was associated with malignant clinicopathological characteristics and poor prognosis in clear cell renal cell carcinoma patients PMID: 26404644
  9. PCDH17 promoter methylation is closely associated with bladder cancer malignancy and may be used as an independent predictor of clinical outcomes in patients with bladder cancer. PMID: 24567353
  10. PCDH17 promoter methylation was significantly associated with malignant behaviour and poor prognosis of bladder cancer PMID: 24366498
  11. This study demonistrated that critical role for PCDH17 in the synaptic development of specific corticobasal ganglia circuits and suggest the involvement of PCDH17 in such circuits in depressive behaviors. PMID: 23684785
  12. PCDH17 acts as a tumour suppressor, exerting its anti-proliferative activity through inducing apoptosis and autophagy, and is frequently silenced in gastric and colorectal cancers. PMID: 22926751
  13. Our study clearly demonstrates that PCDH17 is transcriptionally downregulated in gastric cancer due to aberrant promoter CpG island methylation PMID: 22207556
  14. statistical significant downregulation of PCDH17/PCH68 and PTPRD was observed PMID: 21213369
  15. results suggest that silencing of PCDH17 expression through hypermethylation of the promoter or other mechanisms leads to loss of its tumour-suppressive activity, which may be a factor in the carcinogenesis of a subgroup of ESCCs PMID: 20200074
  16. Azoospermic testis showed down-regulation of CDH18 and PCDH17. PMID: 20180417
  17. the apparent occurrence of an unusual TG 3' splice site in intron 2 is discussed PMID: 17672918

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Subcellular Location
Cell membrane; Single-pass type I membrane protein.
Database Links

HGNC: 14267

OMIM: 611760

KEGG: hsa:27253

UniGene: Hs.106511

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