Code | CSB-YP024011HU |
MSDS | |
Size | Pls inquire |
Source | Yeast |
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Code | CSB-EP024011HU |
MSDS | |
Size | Pls inquire |
Source | E.coli |
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Code | CSB-EP024011HU-B |
MSDS | |
Size | Pls inquire |
Source | E.coli |
Conjugate | Avi-tag Biotinylated E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag. |
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Code | CSB-BP024011HU |
MSDS | |
Size | Pls inquire |
Source | Baculovirus |
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Code | CSB-MP024011HU |
MSDS | |
Size | Pls inquire |
Source | Mammalian cell |
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TNNI1, also known as troponin I1, is a protein that is specifically expressed in slow muscle fibers and plays a crucial role in muscle development [1]. It is primarily expressed in skeletal muscle and functions to prevent actin-myosin interaction, while also being considered a cytoskeletal element in some neurons [2]. Importantly, TNNI1 is associated with age-related skeletal muscle functional decline, as its carbonylation is closely linked to this decline [3]. Furthermore, TNNI1 is located in slow-twitch myofibers and provides a calcium-sensitive switch for the contraction of striated muscle, playing a significant role in muscle growth [4]. In addition, TNNI1 is expressed in the sarcomeres of the fetal heart and in late fetal/early neonatal life, but is not detected in the adult myocardium [5]. TNNI1 is also implicated in oncogenic overgrowth and has been shown to enhance and be required for tumor growth [6]. Moreover, TNNI1 is a gene of fetal muscle troponin and has been associated with meat quality in pigs [7]. It is located at 1q31.3, belongs to the TnI subfamily, and encodes the slow skeletal muscle isoform of TnI, expressed in the skeletal muscle and heart of embryos [8]. Additionally, TNNI1 has been found to interact with other genes and may play a central role in hub gene interactions [9]. Furthermore, TNNI1 is involved in the skeletal longissimus muscle proteome in finishing pigs, with higher levels in type I fibers and degraded slower than TNNI2 protein [10]. Mutations in TNNI1 have been associated with autosomal dominant proximal arthrogryposis, suggesting a dominant negative effect and impairment of the inhibitory function [11]. Lastly, regular aerobic exercise promotes TNNI1 expression, reducing age-related decreases in skeletal muscle function [12].
References:
[1] X. Yan, J. Wang, H. Li, L. Gao, J. Geng, Z. Maet al., "Combined transcriptome and proteome analyses reveal differences in the longissimus dorsi muscle between kazakh cattle and xinjiang brown cattle", Animal Bioscience, vol. 34, no. 9, p. 1439-1450, 2021. https://doi.org/10.5713/ab.20.0751
[2] L. Lu, L. Wei, J. Peirce, X. Wang, J. Zhou, R. Homayouniet al., "Using gene expression databases for classical trait qtl candidate gene discovery in the bxd recombinant inbred genetic reference population: mouse forebrain weight", BMC Genomics, vol. 9, no. 1, p. 444, 2008. https://doi.org/10.1186/1471-2164-9-444
[3] W. Liu, H. Kuang, Y. Xia, Z. Pope, Z. Wang, C. Tanget al., "Regular aerobic exercise‐ameliorated troponin i carbonylation to mitigate aged rat soleus muscle functional recession", Experimental Physiology, vol. 104, no. 5, p. 715-728, 2019. https://doi.org/10.1113/ep087564
[4] W. Sun, M. Shi-ke, Y. Sun, & Y. Han, "Selection signature analysis for important economic traits in sheep (ovis aries)", Indian Journal of Animal Research, no. Of, 2023. https://doi.org/10.18805/ijar.bf-1586
[5] F. Bedada, S. Chan, S. Metzger, L. Zhang, J. Zhang, D. Garryet al., "Acquisition of a quantitative, stoichiometrically conserved ratiometric marker of maturation status in stem cell-derived cardiac myocytes", Stem Cell Reports, vol. 3, no. 4, p. 594-605, 2014. https://doi.org/10.1016/j.stemcr.2014.07.012
[6] S. Casas‐Tintó, A. Maraver, M. Serrano, & A. Ferrús, "Troponin-i enhances and is required for oncogenic overgrowth", Oncotarget, vol. 7, no. 33, p. 52631-52642, 2016. https://doi.org/10.18632/oncotarget.10616
[7] N. Ngu and N. Nhan, "Analysis of troponin i gene polymorphisms and meat quality in mongcai pigs", South African Journal of Animal Science, vol. 42, no. 3, 2012. https://doi.org/10.4314/sajas.v42i3.11
[8] X. Jiang, Y. Chen, Y. Ding, H. Qiu, D. Zhou, & C. Qiu, "Effect of grilled nux vomica on differential rna expression profile of gastrocnemius muscle and toll‑like receptor 4 (tlr-4)/nuclear factor kappa b (nf-κb) signaling in experimental autoimmune myasthenia gravis rats", Medical Science Monitor, vol. 26, 2020. https://doi.org/10.12659/msm.919150
[9] W. Yuan, Y. Deng, E. Ren, G. Zhang, Z. Wu, & Q. Xie, "Analysis of immune infiltration pattern in osteosarcoma and its clinical significance",, 2020. https://doi.org/10.21203/rs.3.rs-91597/v1
[10] X. Ma, C. Zheng, Y. Hu, L. Wang, X. Yang, & Z. Jiang, "Dietary l-arginine supplementation affects the skeletal longissimus muscle proteome in finishing pigs", Plos One, vol. 10, no. 1, p. e0117294, 2015. https://doi.org/10.1371/journal.pone.0117294
[11] Y. Nishimori, A. Iida, M. Ogasawara, M. Okubo, Y. Yonenobu, M. Kinoshitaet al., "tnni1
mutated in autosomal dominant proximal arthrogryposis", Neurology Genetics, vol. 8, no. 1, 2022. https://doi.org/10.1212/nxg.0000000000000649
[12] S. Li, J. Ma, X. Pang, Y. Liang, X. Li, M. Wanget al., "Time-dependent effects of moderate- and high-intensity exercises on
myocardial transcriptomics", International Journal of Sports Medicine, vol. 43, no. 14, p. 1214-1225, 2022. https://doi.org/10.1055/a-1885-4115
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I am looking for a full length Human TNNI1 Recombinant Protein.
I saw CSB-EP024011HU on your website.
(1)Is this full length?
(2)Is this in stock? If not available, what is the lead time?
(3)What are the smaller sizes available besides the 500 ug and 1 mg on the website? Kindly provide pricing on the smaller sizes as well.
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We are interested in 1mg of this product:
CSB-YP015535HU: Human NCL Recombinant Protein [Yeast]-1mg
However, we would like the product to be at least 2mg/ml concentration. We know that this would require producing much more protein, because there is loss in concentration. Also, we would like the protein in PBS, no Tris. And any glycerol or BSA below 20%.
What would be the price for a product like this?