Recombinant Mouse Cytoplasmic polyadenylation element-binding protein 1 (Cpeb1)

1. CPEB1 level was increased in the basolateral amygdala (BLA) of model mice injected with Complete Freund's Adjuvant. CPEB1 knockdown in the BLA can relieve anxiety-like behaviors but not pain-like behaviors by heightening inhibitory transmission and restoring the excitatory/inhibitory balance in model mice. PMID: 29242136
2. CPEB1 regulation of MMP9 mRNA expression mediates metastasis of breast cancer cells PMID: 26411364
3. DAZL and CPEB1 regulate mRNA translation during oocyte maturation. PMID: 26826184
4. Identify a mechanism of VEGF overexpression in liver and mesentery that promotes pathologic, but not physiologic, angiogenesis, via sequential and nonredundant functions of CPEB1 and CPEB4. PMID: 26627607
5. cytoplasmic-element-binding control of transforming growth factor beta-activated kinase 1 mRNA translation mediates the inflammatory immune response PMID: 25452303
6. Myoepithelial cells prevent EMT by influencing the polarity and proliferation of luminal epithelial cells in a mechanism that requires translational silencing of myoepithelial Twist1 by CPEB1. PMID: 24634508
7. Fmr1(-/y); Cpeb1(-/-) double-knockout mice displayed amelioration of biochemical, morphological, electrophysiological and behavioral phenotypes associated with fragile X syndrome. PMID: 24141422
8. poly(A) polymerase Gld2, deadenylase PARN, and translation inhibitory factor neuroguidin (Ngd) are components of a dendritic CPEB-associated polyadenylation apparatus PMID: 22727665
9. CPEB-mediated zonal occludens-1 mRNA localization is essential for tight-junction assembly and mammary epithelial cell polarity PMID: 22334078
10. when the Cpeb1 knockout mice were fed a high-fat diet, their livers became insulin-resistant.Our results show that Cpeb1 regulated translation is a key process involved in insulin signaling PMID: 22253608
11. CPEB deficiency not only increases IL-6 production but also renders the cell incapable of a senescence-promoting response. PMID: 21536657
12. Data suggest that KHDC1B, via its interaction with mCEPB1, may regulate translation of mRNA targets required for oocyte maturation. PMID: 20668163
13. CPEB undergoes Thr 171 phosphorylation at E16.5, but dephosphorylation at the E18.5, when most oocytes are entering diplotene PMID: 12815066
14. Data suggest that CPEB-1 contributes in the translational control of mRNAs that is critical only for some selected forms of long-term potentiation and long-term depression. PMID: 15169862
15. These results demonstrate that CPEB phosphorylation and translation are regulated by CaMKII activity and provide a possible mechanism for how dendritic protein synthesis in the hippocampus may be stimulated during synaptic plasticity PMID: 15175389
16. CPEB binds the small intracellular domain (ICD) of APLP1. PMID: 16314516
17. a new eukaryotic initiation factor 4E (eIF4E) binding protein, Neuroguidin (Ngd), and its interaction with CPEB is described. PMID: 16705177
18. CPEB knockout mouse is sterile but overtly normal, but embryo fibroblasts derived from this mouse (MEF) do not enter senescence in culture as do wild-type MEFs, but instead are immortal. PMID: 17015432
19. CPEB controls the expression of Gdf9 mRNA, which in turn is necessary for oocyte-follicle development. PMID: 17050619
20. CPEB-1 control of c-Jun mRNA translation regulates GH gene expression and resulting downstream signaling events (e.g., synaptic plasticity) in the mouse hippocampus. PMID: 18716208
21. Data identified an interaction of CPEB (cytoplasmic polyadenylation-element-binding protein) 1 and CPEB2 with the 3'-UTR (untranslated region) of HIF-1alpha mRNA. PMID: 18752464

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KEGG: mmu:12877

STRING: 10090.ENSMUSP00000137079

UniGene: Mm.273122