Recombinant Mouse Erythroid transcription factor (Gata1)

1. GATA1 interacts with the STING promoter and activates the basal transcription of the STING gene. PMID: 28522827
2. GATA1 may be a potential regulator of Six2-maintained population of nephron progenitor cells. PMID: 28842839
3. Gata1(low) mice are a bona fide model of MF, which recapitulates the hyperactivation of the TPO/MPL/JAK2 axis observed in megakaryocytes from myelofibrotic patients. PMID: 28622305
4. the Gata-1 gene was a T3-directly regulated gene and that TRa1PV could impair erythropoiesis via repression of the Gata-1 gene and its regulated genes. These results provide new insights into how TRa1 mutants acted to cause erythroid abnormalities in patients with mutations of the THRA gene. PMID: 28910278
5. Gain of function with GATA1 restores the common myeloid precursor differentiation into erythroblasts that was decreased by burn injury. There is a reciprocal relationship between myeloid-specific MafB and erythroid-specific GATA1 in these cells. MafB plays a role in dampening GATA1. PMID: 26992433
6. expression of GATA1 effectively rescued maturation of Primary myelofibrosis megakaryocytes. PMID: 28240607
7. Gata1-KO(DC) DCs have reduced polysialic acid levels on their surface, which is a known determinant for the proper migration of DCs toward CCL21. PMID: 27815426
8. removal of the the Gata1 methylation-determining region -mediated silencing machinery is the molecular basis of the initial activation of the Gata1 gene and erythropoiesis. PMID: 28069743
9. Results show that GATA1 recognizes a single GATA motif or a composite of adjacent GATA motifs and exerts its diversified bindings. These binding configurations serve as one of the critical determinants of specific transcriptional regulation. PMID: 27215385
10. deletion of P-sel disrupted megakaryocyte/neutrophil interactions in spleen, reduced TGF-beta content, and corrected the hematopoietic stem cells distribution that in Gata1(low) mice, as in primary myelofibrosis patients, is abnormally expanded in spleen. PMID: 26439305
11. findings suggest that Gata1 & PU.1 transcription factors are only executing and reinforcing lineage choice once made. These results challenge the current prevailing model of early myeloid lineage choice PMID: 27411635
12. GATA1 and PU.1 bind in vitro and in vivo the proximal promoter region of the RPS19 gene which is frequently mutated in Diamond-Blackfan Anemia. PMID: 26447946
13. TAL1 and GATA1 form a precisely organized complex at a compound motif consisting of a TG 7 or 8 bp upstream of a WGATAA motif across thousands of genomic locations PMID: 26503782
14. immunoprecipitation. Our data provide new insights into the expanded regulatory circuitry that coordinates Nanog expression. PMID: 26296469
15. Scrib is a novel proinflammatory regulator in endothelial cells, which maintains the protein expression of GATA-like protein-1. PMID: 26205961
16. Inducible Gata1 suppression expands megakaryocyte-erythroid progenitors from embryonic stem cells PMID: 25961454
17. By ablating TAF10 specifically in erythroid cells in vivo, observed is a differentiation block accompanied by deregulated GATA1 target genes, including Gata1 itself, suggesting functional cross talk between GATA1 and TAF10. PMID: 25870109
18. GATA-1 deficiency can partially rescue the trabecular bone loss observed with osteoprotegerin deficiency PMID: 25205203
19. the dbGATA motif has a role in the maintenance of Gata1 expression in hematopoietic progenitors PMID: 25535330
20. Genetic deletion of the GATA1-regulated protein alpha-synuclein reduces oxidative stress and nitric oxide synthase levels in mature erythrocytes. PMID: 25043722
21. PSTPIP2 dysregulation contributes to aberrant terminal differentiation in GATA-1-deficient megakaryocytes by activating LYN. PMID: 24407241
22. The results show that all three elements independently and cooperatively contribute to G1HRD activity in vivo in definitive erythropoiesis, although these are contributing redundantly to primitive erythropoiesis. PMID: 24118212
23. preceding binding of GATA2 helps the following binding of GATA1 and thereby secures smooth expression of the transient-phase genes. PMID: 23911012
24. GATA2 plays a more important role than GATA1 in the regulation of most mast cell-specific genes. PMID: 24615013
25. The 3.2-kb sequences interspaced between the Gata1 hematopoietic enhancer & the double GATA-motif were able to recruit DNA methyltransferase 1, exerting a cis-repressive function in hematopoietic stem cells. PMID: 24021675
26. GATA-1 plays an important role in both generation and activation of basophils. PMID: 24167252
27. results suggest that EPO-induced transient phosphorylation of GATA-1 at serine(2) is dispensable for erythropoiesis PMID: 23717580
28. Data indicate a vital link between GATA-1 and the histone H4 lysine 20 methyltransferase PR-Set7/SetD8 (SetD8). PMID: 23959865
29. Although none of the parameters measured were different between the NF-E2 deficient and control mice, an increase in calcium (21%) and an increase in the mineral/matrix ratio (32%) was observed in GATA-1 deficient mice. PMID: 23359245
30. This study demonstrates that Ikaros directly interacts with GATA1, GATA2, and GATA3 as well as Cdk9/P-TEFb through specific protein domains. PMID: 23732910
31. The results suggest that GATA-1 associates preferentially with changes of specific epigenetic modifications, such as H4K16, H3K27 acetylation and H3K4 di-methylation. PMID: 23519611
32. An important functional interplay between Ikaros, GATA factors, and the NOTCH signaling pathway in specification and homeostasis of the megakaryocyte lineage. PMID: 23335373
33. GATA-1, in the absence of FOG-1, occupies GATA-1(V205G)-selective sites. PMID: 22771118
34. Erythropoietin regulates GATA1 through protein kinase D activation, promoting histone deacetylase 5 dissociation from GATA1, and subsequent GATA1 acetylation. PMID: 22983445
35. Gata2 mRNA level was significantly increased while Gata1 was maintained at low levels during the differentiation of mast cells derived from mouse bone marrow. PMID: 22988301
36. results describe a mechanism whereby GATA-1 utilizes Ikaros and Polycomb repressive complex 2 to promote Hes1 repression as an important step in erythroid cell differentiation PMID: 22778136
37. Mitosis-specific destruction of GATA1 delays reactivation selectively of genes that retain GATA1 during mitosis; studies suggest a requirement of mitotic "bookmarking" by GATA1 for the faithful propagation of cell-type-specific transcription programs through cell division. PMID: 22901805
38. GATA1 has two independent transactivation domains, N-TAD and C-TAD. Both N-TAD and C-TAD retain redundant as well as specific activities for proper hematopoiesis in vivo. PMID: 22556427
39. GATA1-HS2 enhancer allows persistent and position-independent expression of a beta-globin transgene PMID: 22164220
40. GATA factors GATA-1 and GATA-2 bind overlapping sets of genes, often at distinct sites, as a means to differentially regulate target gene expression and to regulate the balance between proliferation and differentiation. PMID: 22383799
41. Mature erythrocyte membrane homeostasis is compromised by loss of the GATA1-FOG1 interaction resulting in thrombocytopenia and anemia. PMID: 22279059
42. ZNF268 is a crucial downstream target and effector of GATA-1 PMID: 22235304
43. GATA-1, SCL, and Klf1 form an erythroid core transcriptional network by co-occupying >300 genes PMID: 22357756
44. GATA-1 is specifically required for erythrocyte-lineage commitment. PMID: 22068055
45. c-Myb and GATA-1 act in concert to achieve correct megakaryocytic differentiation. PMID: 21668739
46. Disruption of the GATA1/FOG1/NuRD transcriptional system results in a complex, pleiotropic platelet defect beyond gray platelet syncrome-like macrothrombocytopenia. PMID: 21989988
47. despite extensive changes in gene expression, the chromatin state profiles and accessibility remain largely unchanged during GATA1-induced erythroid differentiation PMID: 21795386
48. Brd3 associates with acetylated GATA1 to promote its chromatin occupancy at erythroid target genes PMID: 21536911
49. Dll1/Notch signaling reduces GATA-1 and GATA-2 expression in bone marrow-derived mast cells. PMID: 21321116
50. Aberrant MYB-GATA1 fusion induces leukemia in the presence of GATA1 reduced levels. PMID: 21252985

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KEGG: mmu:14460

STRING: 10090.ENSMUSP00000033502

UniGene: Mm.335973