Recombinant Mouse Glutamate [NMDA] receptor subunit zeta-1 (Grin1), partial

1. Genetic deletion of the GluN1 subunit, which is required for assembly of functional NMDARs, leads to a strong reduction of GABAergic synaptic transmission. PMID: 29355693
2. Increased PKC activity and altered GSK3B/NMDAR function drive behavior cycling in HINT1-deficient mice. PMID: 28240305
3. Data show that NMDA receptor Grin1(Rgsc174/+) heterozygous missense mutation mice retained increased basal activity and exploring behaviour under a group-housed environment. PMID: 29150978
4. We demonstrate that neocortical neurons that have only one copy of Sip1 (heterozygous, Sip1(fI/wt)), are more sensitive to both NMDA- and AMPA- receptors agonists as compared to wild type neurons (Sip1(wt/wt)). PMID: 28455101
5. Loss of NMDA receptors caused irregularity in activity of noradrenergic neurons, affected exploratory behavior, attention and impulsivity. PMID: 28383797
6. We found that the inducible deletion of the NMDA receptors prior to behavioral assays impaired, not only object and social recognition memory tests, but also resulted in profound deficits in social motivation. Mice with ablated NR1 subunits in the forebrain demonstrated significant decreases in sociability compared to their wild type counterparts. PMID: 27575297
7. Isoflurane relieves zymosan-induced neutrophil inflammatory lung response by targeting NMDA glutamate receptor and Toll-like receptor 2 signaling pathway. PMID: 27144523
8. Sepsis selectively decreased the protein and mRNA levels of GluN2A, GluN2B and GluN1 but not the levels of synaptophysin or the neuronal number in the hippocampus of septic mice. PMID: 29176858
9. The present study provides additional support for roles for GRIN1 in the etiology of depression following early adversity. PMID: 27506655
10. NMDARs are critical for developmental programs involved in appropriate expression of short-term plasticity, AMPA receptor (AMPAR) function and dendrite patterning. PMID: 28751664
11. Study showed that NR1(D1CreERT2) mice lack the ability to associate contextual cues with the rewarding effects of drugs of abuse, with minor or no deficits in other reward-conditioned behaviors or learning in general. PMID: 27294197
12. tau overexpression mediates the excitatory toxicity induced by E-NMDAR activation through inhibiting ERK phosphorylation. PMID: 27809304
13. GluN1 deletions in D1- and A2A-expressing cell types reveal distinct modes of behavioral regulation. The data supports the hypothesis that cell type-specific NMDAR signaling regulates separable behavioral outcomes related to locomotion, despair, and relapse. PMID: 27012890
14. In diabetic mice, knockdown of NR1 using lentivirus carrying NR1-shRNA ameliorated the pathological features associated with diabetic kidney disease. NR1 knockdown decreased the cell shape remodelling, cell collapse, bovine serum albumin permeability, and migration induced by high glucose. PMID: 27338016
15. In a model of depressive disorder, the oxidation of NR1 by NOX1-derived reactive oxygen species was demonstrated in prefrontal cortex. PMID: 28314819
16. NMDAR1 plays a pivotal role in hemin-induced NLRP3-mediated inflammatory damage through synergistic activation. PMID: 26777707
17. Study demonstrated that NMDAR functions are regulated by ghrelin in a GHSR1a-dependent manner: NMDAR-mediated synaptic currents are increased as a result of GluN1 subunit phosphorylation in the hippocampal pyramidal neurons and synapses PMID: 26490687
18. Lysosomal iron modulates NMDA receptor-mediated excitation via small GTPase, Dexras1 PMID: 27080392
19. Deletion of the gene encoding the essential NR1 subunit of the NMDA receptor (NMDAR), restricted to the CA1 region of the hippocampus results in abnormal fear response in mice. PMID: 25786918
20. Heterozygous NR1 (+/-) mice with reduced glutamate function are more sensitive to the disruptive effects of social isolation. PMID: 25461194
21. EphB2 prevents amyloid-beta-induced depletion of cell surface GluN1 requiring the PDZ-binding motif of EphB2 PMID: 26589795
22. The authors demonstrate that nascent granule cells lacking NMDARs but rescued from apoptosis by overexpressing the pro-survival protein Bcl2 were deficient in spine formation. PMID: 26473971
23. Endogenous synaptic as well as tonic zinc inhibits extrasynaptic NMDARs and thereby fine tunes neuronal excitability and signaling. PMID: 25947151
24. GluN1 expression/enhanced glutamatergic function facilitates improved spatial memory in aldehyde dehydrogenase 2 deficient mice. PMID: 25467136
25. Study compared neuronal injury in the hippocampal CA1 region to that in PCs and investigated the role of NMDA receptors GluN2B and GluN1 in Purkinje cell injury in a mouse model of cardiac arrest and cardiopulmonary resuscitation PMID: 25450957
26. Results suggest that NMDA-receptor(Grin1)-mediated synaptic plasticity in the dorsal striatum contributes to strategy shifting and that striatal projection neurons of the direct pathway are particularly relevant for this process PMID: 25446363
27. Studied whether H2S supplementation reduces NMDA-R and MMP-9-induced dysfunction in diabetic kidney. PMID: 25659756
28. Studies provide evidence that N-methyl-D-aspartate receptor dependent neural signaling in the mPFC is a component of a neural mechanism for disambiguating the meaning of fear signals. PMID: 25615540
29. This study demonstrated that the knockout of the GRIN1 gene that a selective decrease in dentate gyrus GluN1 is sufficient to decrease the glutamate concentrations . PMID: 24912493
30. findings suggest that medial prefrontal cortex and CA3 hippocampus glutamate N-methyl-D-aspartate receptors play selective roles in regulating compulsive and impulsive behavior, respectively. PMID: 25452020
31. Results demonstrate for the first time that NMDAR1 hypofunction in pyramidal cells is sufficient to cause electrophysiological, molecular, neuropathological, and behavioral changes PMID: 25156700
32. Presynaptic c-Jun N-terminal Kinase 2 regulates NMDA receptor-dependent glutamate release. PMID: 25762148
33. Prion protein C and copper support NMDAR S-nitrosylation and cooperatively exert neuroprotection. PMID: 25490055
34. NR1 knockdown mice showed sex differences in onset and severity of hyperlocomotion, stereotypy, memory deficits and social behavior. PMID: 25327402
35. Studies suggest that NMDAR hypofunction in NR1 knockdown mice causes increased dopamine neuron firing and synaptically elevated dopamine, but this does not lead strictly to the same state of hyperdopaminergia as acute NMDAR antagonism PMID: 24754704
36. results indicate that NMDA Receptor hypofunction critically contributes to FrontoTtemporal Dementia-associated behavioral and electrophysiological alterations. PMID: 25471585
37. The results of this study demonstrated that presynaptic Grin1 are equally important as postsynaptic NMDARs in LTP induction of corticostriatal synapses due to their role in mediating activity-induced presynaptic BDNF secretion. PMID: 25467984
38. No difference in CA1 hippocampus place cell activity was found between control and knockout mice lacking the NMDAR1 receptor. PMID: 25429128
39. Grin 1 is identified as a novel Cdk5 substrate and MARCKS is confirmed as a Cdk5 substrate. PMID: 24658276
40. The data obtained indicate that modified neurons are the result of seizures suffered by the animals in the course of PTZ kindling, and that the blockade of NMDA glutamate receptors can suppress manifestations of seizures PMID: 25434216
41. Targeted elimination of GRIN1 in thalamus impairs sensorimotor and cognitive functions. PMID: 25186746
42. It causes neuronal dysfunction and death, presumably due to excess calcium influx. PMID: 24094580
43. results of this study indicate that adolescent social isolation produces a selective redistribution of NR1 subunits in dendritic spines of projection neurons in the basolateral amygdala PMID: 24231734
44. NMDAR-dependent neurotransmission is not necessary to regulate depression-like behaviors in a mouse model. PMID: 24454710
45. Study implicates NMDAR subunits NR1, NR2A, and NR2B in the variability associated with the development of ethanol sensitization PMID: 24315834
46. Hippocampal NMDARs, particularly in CA1, act as part of a comparator system to detect and resolve conflicts arising when two competing, behavioural response options are evoked concurrently. PMID: 24298151
47. alpha7nAchR/NMDAR coupling may selectively affect some aspects of learning and memory. PMID: 24360204
48. The data of this study suggested that L4 neurons have "fluctuating" dendrites during TC reorganization and that nr1 cell autonomously regulate these dynamics to establish fine-tuned circuits. PMID: 24685175
49. Increases in N1 latency, impaired sociability, and reduced vocalizations in PV-selective NR1 KO mice mimic similar changes found in autism. PMID: 23441094
50. deletion of the Grin1 gene impairs the synaptic efficacy between the primary somatosensory and primary motor cortices and significantly reduces classically conditioned eyeblink responses. PMID: 23978820

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KEGG: mmu:14810

STRING: 10090.ENSMUSP00000028335

UniGene: Mm.278672