Recombinant Mouse Hypoxanthine-guanine phosphoribosyltransferase (Hprt1)

1. The HGprt deficiency in mice is associated with a decrease in colon contractility. PMID: 29305058
2. This study showed that in HPRT knockout mouse brain did not find any abnormalities change Neurotransmitter and their metabolite concentrations. PMID: 27206901
3. six metabolites with significantly different contents in wild-type and HPRT-deficient mice, were found. PMID: 27221022
4. In the HGprt-deficient mouse model, stains for tyrosine hydroxylase (TH) reveal no obvious loss of midbrain dopamine neurons, but quantitative immunoblots reveal reduced TH expression in the striatum. PMID: 24891139
5. HPRT-deficiency alters cAMP/PKA signaling pathway, which is in part due to the increased of PDE10A expression and activi PMID: 23691025
6. Hprt is proposed as a reference gene for analysis of gene expression in neural developmental issues of the murine neocortex. PMID: 22735032
7. Data indicate that Ubc and Ywhaz were best correlated for cB cells and lymphocytes, whereas Ubc and Gapdh were the best combination for non-B cells, and Actb and Hprt1 were the least stably expressed genes for B cells and non-B cell. PMID: 22884776
8. Data indicate that Hprt, Rpl13a and Tpt1 are a set of stably expressed reference genes for accurate gene expression normalization in myocardial infarction studies in mice. PMID: 21858224
9. These results demonstrate that PRTFDC1 is a genetic modifier of HPRT-deficiency in the mouse. PMID: 21818316
10. ionizing radiation-induced mutant phenotype plasticity is not dependent on DNA methylation of the hypoxanthine phosphoribosyl transferase gene in mouse FM3A cells PMID: 21248429
11. Hprt mutant frequencies were determined in aging male rats on caloric restriction diets. PMID: 12787914
12. Study suggests that mice chronically treated with azathioprine have elevated Hprt mutations due to clonal amplification of Hprt mutants. PMID: 16107271
13. In order to determine the effect of Pms2-deficiency on mutation, mutant frequencies in the endogenous Hprt gene of lymphocytes from male Pms2(-/-), Pms2(+/-), and Pms2(+/+) mice, was measured. PMID: 16336979
14. These results suggest that dopamine loss in HPRT deficiency has a biochemical rather than anatomical basis and imply that purine recycling to be a biochemical process of particular importance to the function of dopaminergic neurons. PMID: 17374562
15. genetic consequences of a primary HPRT knockout in the mouse produces transcriptional aberrations in a number of other genes that may play a role in the disease phenotype PMID: 17505472
16. Purine recycling is an intrinsic metabolic process crucial to the molecular phenotype of dopaminergic neurons independent of previously established mechanisms involving energy failure, oxidative stress, or proteasome dysfunction. PMID: 18313225
17. NAD concentration and enzyme activities were found to be significantly increased in liver, but not in brain or blood of HPRT knockout mice. PMID: 19319672
18. HPRT deficiency influences the development of dopamine neurons and their neurochemical phenotype. PMID: 19342420

Show More

Hide All

KEGG: mmu:15452

STRING: 10090.ENSMUSP00000026723

UniGene: Mm.299381