Recombinant Mouse Poly [ADP-ribose] polymerase 2 (Parp2)

1. PARP2 is preferentially activated by poly(ADP-ribose) (PAR) and subsequently catalyzes branched PAR chain synthesis. PMID: 30104678
2. Peripheral T-cell number was not affected in single PARP-2-deficient mice. Double-deficiency in PARP-1/PARP-2 in T-cells led to highly aggressive T-cell lymphomas. PMID: 28181505
3. PARP2 protein deficiency protected mice from Concanavalin A -induced Liver Damage. PMID: 28751426
4. Activation of either PARP-1 or -2 is likely to play a role in muscle protein catabolism via oxidative stress, NF-kappaB signaling, and enhanced proteasomal degradation in cancer-induced cachexia. PMID: 28177129
5. PARP1/2 inhibitor simmiparib causes growth inhibition in cancer cell- or tissue-derived xenografts in nude mice. PMID: 27847302
6. The findings highlight specific non-overlapping functions of PARP1 and PARP2 at H2AX-deficient chromatin during replicative phases of the cell cycle and uncover a unique requirement for PARP1 in nonhomologous end-joining-deficient cells. PMID: 27373144
7. Data show reduced tumor burden through increased oxidative stress in lung adenocarcinoma cells of PARP-1 and PARP-2 knockout mice. PMID: 26700152
8. PARP-2 has an essential role in erythropoiesis by limiting replicative stress in erythroid progenitors. PMID: 25501596
9. PARP-1 and -2 play a role in cancer-induced cachexia, thus selective pharmacological inhibition of PARP-1 and -2 may be of interest in clinical settings PMID: 26432600
10. the depletion of PARP-2 leads to lower HDL levels which represent a risk factor to cardiovascular diseases. PMID: 24365238
11. This study represents the first description of a significant role for PARP-2 in neuroinflammation and neurological dysfunction in Experimental autoimmune encephalomyelitis PMID: 23607899
12. our data show that PARP-2 can directly regulate base excision repair proteins PMID: 23357680
13. Our results show that Parp-2 plays essential roles in the surveillance of genome integrity of stem cell hematopoiesis by orchestrating DNA repair and restraining p53-induced and Puma-mediated apoptosis. PMID: 23678004
14. PARP2 activity mobilizes intracellular TRPM2 channels in a Parp1-/- background. PMID: 22751932
15. Identify PARP-2 as a mediator of doxorubicin toxicity by regulating vascular SIRT1 activity and mitochondrial biogenesis. PMID: 21921080
16. Inhibition of PARP1 and PARP2 (by genetic or pharmacological means) leads to increased TOP2B activity in elongating spermatids. PMID: 21228215
17. PARP-2 deletion in mice increases SIRT1 levels, promotes energy expenditure, and increases mitochondrial content. PMID: 21459329
18. role of PARP-2 activity in the maintenance of telomere integrity; PARP-2 physically binds to TRF2 with high affinity PMID: 14749375
19. crystal structure of the catalytic fragment of murine PARP-2, at 2.8 A resolution PMID: 14739238
20. We conclude that PARP-2 contributes substantially to nuclear translocation of AIF and infarct size after transient focal cerebral ischemia in male mice, but that protection is disproportionate to the attenuation of overall PARP activity. PMID: 20236222
21. a synergistic interaction between Parp-2 and p53 in tumour suppression through the role of Parp-2 in DNA-damage response and genome integrity surveillance PMID: 20154718
22. Caspase-8 not only triggers and amplifies the apoptotic process at cytoplasmic sites but can also act as an executioner at nuclear levels where it cleaves PARP-2 PMID: 12065591
23. functional interaction with poly ADP ribose pomymerase 1 and role of that interaction in chromosome stability and embryo development PMID: 12727891
24. genetic interactions between PARP-1, PARP-2, Atm play an essential role during early embryogenesis [review] PMID: 15279798
25. role for PARP-2 as an important mediator of T-cell survival during thymopoiesis by preventing the activation of DNA damage-dependent apoptotic response during the multiple rounds of TCRalpha rearrangements preceding a positively selected TCR PMID: 16946705
26. These findings indicate that, in addition to its well known role in DNA repair, Parp-2 exerts essential functions during meiosis I and haploid gamete differentiation. PMID: 17001008
27. PPAR-2 controls adipocyte differentiation and adipose tissue function through the regulation of the activity of the retinoid X receptor/PPARgamma heterodimer PMID: 17951580
28. These results provide evidence that acetylation of PARP-2 is a key post-translational modification that may regulate DNA binding and consequently also the enzymatic activity of PARP-2. PMID: 18436469
29. Selective PARP-2 inhibitors increase apoptosis in hippocampal slices but protect cortical cells in models of post-ischaemic brain damage. PMID: 19422384
30. Data show that Parp2 interacts significantly with both the transition protein TP2 and the transition chaperone HSPA2, whereas Parp1 binds weakly to HSPA2. PMID: 19607827

Show More

Hide All

KEGG: mmu:11546

STRING: 10090.ENSMUSP00000048877

UniGene: Mm.281482